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Image-Based Modeling Reveals Dynamic Redistribution of DNA Damageinto Nuclear Sub-Domains

Description: Several proteins involved in the response to DNA doublestrand breaks (DSB) f orm microscopically visible nuclear domains, orfoci, after exposure to ionizing radiation. Radiation-induced foci (RIF)are believed to be located where DNA damage occurs. To test thisassumption, we analyzed the spatial distribution of 53BP1, phosphorylatedATM, and gammaH2AX RIF in cells irradiated with high linear energytransfer (LET) radiation and low LET. Since energy is randomly depositedalong high-LET particle path… more
Date: August 3, 2007
Creator: Costes Sylvain V.; Ponomarev, Artem; Chen, James L.; Nguyen, David; Cucinotta, Francis A. & Barcellos-Hoff, Mary Helen
Partner: UNT Libraries Government Documents Department
open access

Environmental Challenges for the Nuclear Diagnostics on the NIF and LMJ

Description: The National Ignition Facility (NIF) and Laser Mega Joule (LMJ) facilities are currently under construction in the United States and France. Ignited targets at these facilities are anticipated to produce up to 1019 deuterium-tritium fusion neutrons. This will provide unprecedented opportunities and challenges for the use of nuclear diagnostics in inertial confinement fusion experiments. The NIF and LMJ nuclear diagnostics will work in a harsh radiation environment that includes neutron, hard x-… more
Date: June 27, 2007
Creator: al., K. Miller et
Partner: UNT Libraries Government Documents Department
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Horizontal gene transfer and the evolution of transcriptionalregulation in Escherichia coli

Description: Background: Most bacterial genes were acquired by horizontalgene transfer from other bacteria instead of being inherited bycontinuous vertical descent from an ancient ancestor}. To understand howthe regulation of these {acquired} genes evolved, we examined theevolutionary histories of transcription factors and of regulatoryinteractions from the model bacterium Escherichia coli K12. Results:Although most transcription factors have paralogs, these usually arose byhorizontal gene transfer rather t… more
Date: December 20, 2007
Creator: Price, Morgan N.; Dehal, Paramvir S. & Arkin, Adam P.
Partner: UNT Libraries Government Documents Department
open access

Mechanical and charge transport properties of alkanethiol self-assembled monolayers on Au (111) surface: The Role of Molecular Tilt

Description: The relationship between charge transport and mechanical properties of alkanethiol self-assembled monolayers (SAM) on Au(111) films has been investigated using an atomic force microscope with a conductive tip. Molecular tilts induced by the pressure applied by the tip cause stepwise increases in film conductivity. A decay constant {beta} = 0.57 {+-} 0.03 {angstrom}{sup -1} was found for the current passing through the film as a function of tip-substrate separation due to this molecular tilt. Th… more
Date: November 12, 2007
Creator: Mulleregan, Alice; Qi, Yabing; Ratera, Imma; Park, Jeong Y.; Ashby, Paul D.; Quek, Su Ying et al.
Partner: UNT Libraries Government Documents Department
open access

R. Bruce Merrifield and Solid-Phase Peptide Synthesis: A Historical Assessment

Description: Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid-phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges wer… more
Date: December 4, 2007
Creator: Mitchell, A R
Partner: UNT Libraries Government Documents Department
open access

Operation of a Free-Electron Laser from the Extreme Ultraviolet to the Water Window

Description: We report results on the performance of a free-electron laser operating at a wavelength of 13.7 nm where unprecedented peak and average powers for a coherent extreme-ultraviolet radiation source have been measured. In the saturation regime, the peak energy approached 170 {micro}J for individual pulses, and the average energy per pulse reached 70 {micro}J. The pulse duration was in the region of 10 fs, and peak powers of 10 GW were achieved. At a pulse repetition frequency of 700 pulses per seco… more
Date: December 17, 2007
Creator: Ackermann, W.; Asova, G.; Ayvazyan, V.; Azima, A.; Baboi, N.; Bahr, J. et al.
Partner: UNT Libraries Government Documents Department
open access

X-ray spectroscopic study of the charge state and local orderingof room-temperature ferromagnetic Mn oped ZnO

Description: The charge state and local ordering of Mn doped into a pulsed laser deposited single-phase thin film of ZnO are investigated by using X-ray absorption spectroscopy at the O K-, Mn K- and L-edges, and X-ray emission spectroscopy at the O K- and Mn L-edge. This film is found to be ferromagnetic at room temperature. EXAFS measurement shows that Mn{sup 2+} replaces Zn site in tetrahedral symmetry, and there is no evidence for either metallic Mn or MnO in the film. Upon Mn doping, the top of O 2p va… more
Date: August 7, 2007
Creator: Guo, J.-H.; Gupta, Amita; Sharma, Parmanand; Rao, K.V.; Marcus,M.A.; Dong, C.L. et al.
Partner: UNT Libraries Government Documents Department
open access

Plan for Using Solar-Powered Jack Pumps to Sample Groundwater at the Nevada Test Site

Description: Groundwater is sampled from 39 monitoring wells on the Nevada Test Site (NTS) as part of the Routine Radiological Environmental Monitoring Program. Many of these wells were not designed or constructed for long-term groundwater monitoring. Some have extensive completion zones and others have obstructions such as pumps and tubing. The high-volume submersible pumps in some wells are unsuitable for long-term monitoring and result in large volumes of water that may have to be contained and character… more
Date: May 3, 2007
Creator: David Hudson, Charles Lohrstorfer, Bruce Hurley
Partner: UNT Libraries Government Documents Department
open access

Book Review Geostatistical Analysis of Compositional Data

Description: Compositional data are represented as vector variables with individual vector components ranging between zero and a positive maximum value representing a constant sum constraint, usually unity (or 100 percent). The earth sciences are flooded with spatial distributions of compositional data, such as concentrations of major ion constituents in natural waters (e.g. mole, mass, or volume fractions), mineral percentages, ore grades, or proportions of mutually exclusive categories (e.g. a water-oil-r… more
Date: March 26, 2007
Creator: Carle, S F
Partner: UNT Libraries Government Documents Department
open access

Electron cooling rates characterization at Fermilab's Recycler

Description: A 0.1 A, 4.3 MeV DC electron beam is routinely used to cool 8 GeV antiprotons in Fermilab's Recycler storage ring [1]. The primary function of the electron cooler is to increase the longitudinal phase-space density of the antiprotons for storing and preparing high-density bunches for injection into the Tevatron. The longitudinal cooling rate is found to significantly depend on the transverse emittance of the antiproton beam. The paper presents the measured rates and compares them with calculati… more
Date: June 1, 2007
Creator: Prost, Lionel R. & Shemyakin, A.
Partner: UNT Libraries Government Documents Department
open access

New experimental capabilities and theoretical insights of high pressure compression waves

Description: Currently there are three platforms that offer quasi-isentropic compression or ramp-wave compression (RWC): light-gas gun, magnetic flux (Z-pinch), and laser. We focus here on the light-gas gun technique and on some current theoretical insights from experimental data. A gradient impedance through the length of the impactor provides the pressure pulse upon impactor to the subject material. Applications and results are given concerning high-pressure strength and liquid to solid, phase transition … more
Date: July 20, 2007
Creator: Orlikowski, D.; Nguyen, J.; Patterson, J. R.; Minich, R.; Martin, L. P. & Holmes, N.
Partner: UNT Libraries Government Documents Department
open access

Progress with Tevatron Electron Lenses

Description: No Description Available.
Date: September 13, 2007
Creator: Kamerdzhiev, V.; Alexahin, Y.; Kuznetsov, G. F.; Shiltsev, V. D. & Zhang, X.
Partner: UNT Libraries Government Documents Department
open access

Direct Assay of Filter Media following DEOX Testing

Description: The direct assay of filter media by gamma spectrometry following DEOX testing has distinct advantages over analytical chemistry. Prior to using gamma spectrometry for the quantification of cesium (Cs-137), a calibration must be established with known sources since gamma spectrometry yields relative results. Quantitative analytical chemistry, in particular ICP-MS, has been performed on the filter media for comparison to the gamma spectrometry data. The correlation of gamma spectrometry to ICP-MS… more
Date: September 1, 2007
Creator: Lind, R. P.; Giglio, J. J.; Cummings, D. G.; Huntley, M. W.; Morgan, C. D.; Bateman, K. J. et al.
Partner: UNT Libraries Government Documents Department
open access

Theory and Fluid Simulations of Boundary Plasma Fluctuations

Description: Theoretical and computational investigations are presented of boundary plasma microturbulence that take into account important effects of the geometry of diverted tokamaks--in particular, the effect of x-point magnetic shear and the termination of field lines on divertor plates. We first generalize our previous 'heuristic boundary condition' which describes, in a lumped model, the closure of currents in the vicinity of the x-point region to encompass three current-closure mechanisms. We then us… more
Date: January 9, 2007
Creator: Cohen, R. H.; LaBombard, B.; LoDestro, L. L.; Rognlien, T. D.; Ryutov, D. D.; Terry, J. L. et al.
Partner: UNT Libraries Government Documents Department
open access

Coherent neutrino-nucleus scattering and the MINERvA experiment

Description: In this paper we describe the capabilities of the MINERvA experiment for the measurement of neutrino-nucleus coherent scattering.
Date: January 1, 2007
Creator: Gallagher, H.; U., /Tufts; Harris, Deborah & /Fermilab
Partner: UNT Libraries Government Documents Department
open access

Assessing Recharge and Geological Model Uncertainty at the Climax Mine Area of the Nevada Test Site

Description: Hydrologic analyses are commonly based on a single conceptual-mathematical model. Yet hydrologic environments are open and complex, rendering them prone to multiple interpretations and mathematical descriptions. Considering conceptual model uncertainty is a critical process in hydrologic uncertainty assessment. This study assesses recharge and geologic model uncertainty for the Climax mine area of the Nevada Test Site, Nevada. Five alternative recharge models have been independently developed f… more
Date: November 8, 2007
Creator: Ye, M.; Pohlmann, K.; Chapman, J. & Pohll, G.
Partner: UNT Libraries Government Documents Department
open access

New Equalizers for Antiproton Stochastic Cooling at Fermilab

Description: In the continuous effort to improve antiproton stacking rate, a new type of equalizers has been developed and installed in antiproton accumulator. The R&D of these new equalizers is described in this paper. Equalizers are used in Fermilab antiproton stochastic cooling to compensate frequency response of the cooling system. Usually both amplitude and phase compensations are needed. However in most cases it is difficult to achieve a satisfactory compensation for both because of their interdep… more
Date: September 13, 2007
Creator: Lebedev, V. A.; Pasquinelli, R. J. & Sun, D.
Partner: UNT Libraries Government Documents Department
open access

Compensatory Paracrine Mechanisms That Define The Urothelial Response to Injury in Partial Bladder Outlet Obstruction

Description: Diseases and conditions affecting the lower urinary tract are a leading cause of dysfunctional sexual health, incontinence, infection, and kidney failure. The growth, differentiation, and repair of the bladder's epithelial lining are regulated, in part, by fibroblast growth factor (FGF)-7 and -10 via a paracrine cascade originating in the mesenchyme (lamina propria) and targeting the receptor for FGF-7 and -10 within the transitional epithelium (urothelium). The FGF-7 gene is located at the… more
Date: June 21, 2007
Creator: Bassuk, James; Lendvay, Thomas S.; Sweet, Robert; Han, Chang-Hee; Soygur, Tarkan; Cheng, Jan-Fang et al.
Partner: UNT Libraries Government Documents Department
open access

Control of the Magnetic and Magnetotransport Properties of La0.67Sr0.33MnO3 Thin Films Through Epitaxial Strain

Description: The influence of epitaxial strain, in the form of tetragonal distortions, on the magnetic and magnetotransport properties of La{sub 0.67}Sr{sub 0.33}MnO{sub 3} thin films was studied. The tetragonal distortion (c/a ratio) was modulated through the choice of the substrate, ranging from c/a=1.007 on (001)-oriented (LaAlO{sub 3}){sub 0.3}(Sr{sub 2}AlTaO{sub 6}){sub 0.7} substrates to 0.952 on (110)-oriented GdScO{sub 3} substrates. In agreement with previous theoretical predictions, these large va… more
Date: December 20, 2007
Creator: Arenholz, Elke; Takamura, Y.; Chopdekar, R.V.; Arenholz, E. & Suzuki, Y.
Partner: UNT Libraries Government Documents Department
open access

Searches for standard model Higgs at the Tevatron

Description: A summary of the latest results of Standard Model Higgs boson searches from CDF and D0 presented at the DIS 2007 conference is reported in this paper. All analyses presented use 1 fb{sup -1} of Tevatron data. The strategy of the different analyses is determined by the Higgs production mechanism and decay channel.
Date: April 1, 2007
Creator: Vilar Cortabitarte, Rocio & /Cantabria U., Santander
Partner: UNT Libraries Government Documents Department
open access

Certifying Industrial Energy Efficiency Performance: AligningManagement, Measurement, and Practice to Create Market Value

Description: More than fifteen years after the launch of programs in theU.K. and U.S., industry still offers one of the largest opportunities forenergy savings worldwide. The International Energy Agency (IEA) estimatesthe savings potential from cost-optimization of industrial motor-drivensystems alone at 7 percent of global electricity use. The U.S. Departmentof Energy (USDOE) Industrial Technologies Program estimates 7 percentsavings potential in total US industrial energy use through theapplication of pro… more
Date: July 1, 2007
Creator: McKane, Aimee; Scheihing, Paul & Williams, Robert
Partner: UNT Libraries Government Documents Department
open access

Selective extraction of copper, mercury, silver and palladium ionsfrom water using hydrophobic ionic liquids.

Description: Extraction of dilute metal ions from water was performed near room temperature with a variety of ionic liquids. Distribution coefficients are reported for fourteen metal ions extracted with ionic liquids containing cations 1-octyl-4-methylpyridinium [4MOPYR]{sup +}, 1-methyl-1-octylpyrrolidinium [MOPYRRO]{sup +} or 1-methyl-1-octylpiperidinium [MOPIP]{sup +}, and anions tetrafluoroborate [BF{sub 4}]{sup +}, trifluoromethyl sulfonate [TfO]{sup +} or nonafluorobutyl sulfonate [NfO]{sup +}. Ionic … more
Date: June 25, 2007
Creator: Papaiconomou, Nicolas; Lee, Jong-Min; Salminen, Justin; VonStosch, Moritz & Prausnitz, John M.
Partner: UNT Libraries Government Documents Department
open access

Quench performance of Nb3Sn cos-theta coils made of 108/127 RRP strands

Description: A series of 1-m long Nb{sub 3}Sn dipole models has been built at Fermilab in an attempt to refine the wind-and-react technology for Nb3Sn accelerator magnets. Three models made with Powder-in-Tube Nb{sub 3}Sn strand reached their design field of 10 T demonstrating a good reproducibility of magnet quench performance and field quality. Recently a new dipole 'mirror' model based on Nb{sub 3}Sn coil made of improved Restack Rod Process strand was constructed and tested reaching the maximum field ab… more
Date: July 1, 2007
Creator: Zlobin, A.V.; Ambrosio, G.; Andreev, N.; Barzi, E.; Bossert, R.; Carcagno, R. et al.
Partner: UNT Libraries Government Documents Department
open access

Radio-loud high-redshift protogalaxy canidates in Bootes

Description: We used the Near Infrared Camera (NIRC) on Keck I to obtain K{sub s}-band images of four candidate high-redshift radio galaxies selected using optical and radio data in the NOAO Deep Wide-Field Survey in Bootes. Our targets have 1.4 GHz radio flux densities greater than 1 mJy, but are undetected in the optical. Spectral energy distribution fitting suggests that three of these objects are at z > 3, with radio luminosities near the FR-I/FR-II break. The other has photometric redshift z{sub pho… more
Date: July 20, 2007
Creator: Croft, S.; van Breugel, W.; Brown, M. J.; de Vries, W.; Dey, A.; Eisenhardt, P. et al.
Partner: UNT Libraries Government Documents Department
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