The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor

Thumbnail image of item number 1 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.
Thumbnail image of item number 2 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.
Thumbnail image of item number 3 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.
Thumbnail image of item number 4 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.
Showing 1-4 of 141 pages in this thesis.

PDF Version Also Available for Download.

Description

This study examined the effects of chronic ethanol intake on the density, affinity, and allosteric modulation of rat brain GABAA receptor subtypes. In the presence of GABA, the apparent affinity for the benzodiazepine agonist flunitrazepam was increased and for the inverse agonist R015-4513 was decreased. No alteration in the capacity of GABA to modulate flunitrazepam and R015-4513 binding was observed in membranes prepared from cortex, hippocampus or cerebellum following chronic ethanol intake or withdrawal. The results also demonstrate two different binding sites for [3H]RO 15-4513 in rat cerebellum that differ in their affinities for diazepam. Chronic ethanol treatment and withdrawal … continued below

Physical Description

vii, 133 leaves : ill.

Creation Information

Chen, Jianping May 1992.

Context

This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by the UNT Libraries to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 197 times. More information about this thesis can be viewed below.

Who

People and organizations associated with either the creation of this thesis or its content.

Author

Chair

Committee Members

Publisher

Rights Holder

For guidance see Citations, Rights, Re-Use.

  • Chen, Jianping

Provided By

UNT Libraries

The UNT Libraries serve the university and community by providing access to physical and online collections, fostering information literacy, supporting academic research, and much, much more.

About | Browse this Partner

Contact Us

Corrections Questions

What

Descriptive information to help identify this thesis. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

This study examined the effects of chronic ethanol intake on the density, affinity, and allosteric modulation of rat brain GABAA receptor subtypes. In the presence of GABA, the apparent affinity for the benzodiazepine agonist flunitrazepam was increased and for the inverse agonist R015-4513 was decreased. No alteration in the capacity of GABA to modulate flunitrazepam and R015-4513 binding was observed in membranes prepared from cortex, hippocampus or cerebellum following chronic ethanol intake or withdrawal. The results also demonstrate two different binding sites for [3H]RO 15-4513 in rat cerebellum that differ in their affinities for diazepam. Chronic ethanol treatment and withdrawal did not significantly change the apparent affinity or density of these two receptor subtypes.

Physical Description

vii, 133 leaves : ill.

Subjects

Keywords

Library of Congress Subject Headings

Language

Item Type

Identifier

Unique identifying numbers for this thesis in the Digital Library or other systems.

Collections

This thesis is part of the following collection of related materials.

UNT Theses and Dissertations

Theses and dissertations represent a wealth of scholarly and artistic content created by masters and doctoral students in the degree-seeking process. Some ETDs in this collection are restricted to use by the UNT community.

About | Browse this Collection

What responsibilities do I have when using this thesis?

Digital Files

When

Dates and time periods associated with this thesis.

Creation Date

  • May 1992

Added to The UNT Digital Library

  • March 9, 2015, 8:15 a.m.

Description Last Updated

  • March 28, 2019, 9:57 p.m.

Usage Statistics

When was this thesis last used?

Yesterday: 0
Past 30 days: 0
Total Uses: 197
More Statistics

Interact With This Thesis

Here are some suggestions for what to do next.

Start Reading

Thumbnail image of item number 1 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.
Thumbnail image of item number 2 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.
Thumbnail image of item number 3 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.
Thumbnail image of item number 4 in: 'The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor'.

PDF Version Also Available for Download.

Citations, Rights, Re-Use

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Links for Robots

Helpful links in machine-readable formats.

Archival Resource Key (ARK)

International Image Interoperability Framework (IIIF)

Metadata Formats

Images

URLs

Stats

Chen, Jianping. The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor, thesis, May 1992; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc501231/: accessed May 26, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

Back to Top of Screen