Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine

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Article on the protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine.

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6 p.

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Duncan, Scott R.; Xin, Hua; Goad, Daryl L.; Chapman, Kent D. & Koulen, Peter April 22, 2011.

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Article on the protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine.

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6 p.

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Abstract: Retinal ganglion cell (RGC) death is a hallmark of neurodegenerative diseases and disease processes of the eye, including glaucoma. The protection of RGCs has been an important strategy for combating glaucoma, but little clinical success has been reported to date. One pathophysiological consequence of glaucoma is excessive extracellular glutamate subsequently leading to excitotoxicity in the retina. Endocannabinoids, such as the N-acylethanolamine (NAE), arachidonylethanolamine (NAE 20:4), exhibit neuroprotective properties in some models of neurodegenerative disease. The majority of NAEs, however, are not cannabinoids, and their physiological function is not clear. Here, we determined whether the noncannabinoid NAE, linoleoylethanolamine (NAE 18:2), protects neurons in the RGC layer against glutamate excitotoxicity in ex-vivo retina cultures. Using a terminal deoxynucleotidyl transferase-mediated dUTP (2'-deoxyuridine 5'-triphosphate) nick-end labeling (TUNEL) assay, we determined that NAE (18:2) reduces the number of apoptotic RGC layer neurons in response to glutamate and conclude that NAE 18:2 is a neuroprotective compound with potential for treating glaucomatous retinopathy.

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  • Clinical Ophthalmology, 2011(5), Dove Medical Press, April 22, 2011, pp. 1-6

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  • Publication Title: Clinical Ophthalmology
  • Volume: 2011
  • Issue: 5
  • Page Start: 543
  • Page End: 548
  • Peer Reviewed: Yes

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  • April 22, 2011

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  • March 14, 2014, 8:48 a.m.

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  • Nov. 21, 2023, 1:16 p.m.

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Duncan, Scott R.; Xin, Hua; Goad, Daryl L.; Chapman, Kent D. & Koulen, Peter. Protection of neurons in the retinal ganglion cell layer against excitotoxicity by the N-acylethanolamine, N-linoleoylethanolamine, article, April 22, 2011; [Princeton, New Jersey]. (https://digital.library.unt.edu/ark:/67531/metadc277304/: accessed May 29, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Arts and Sciences.

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