Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring

Askins, Lexie; Orimoloye, Helen T.; Deng, Chuanjie; Hansen, Johnni; Olsen, Jorn; Ritz, Beate; Janzen, Carla; Heck, Julia E.

doi:10.1007/s10552-023-01745-4

Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring

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Article states that preeclampsia is a serious pregnancy complication that presents a significant risk to both the mother and the fetus. The authors examined the association between preeclampsia, antihypertensive medications, and childhood cancer in offspring.

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11 p.

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Askins, Lexie; Orimoloye, Helen T.; Deng, Chuanjie; Hansen, Johnni; Olsen, Jorn; Ritz, Beate et al. August 3, 2023.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by the UNT College of Health and Public Service to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 24 times, with 24 in the last month. More information about this article can be viewed below.

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Askins, Lexie University of California, Los Angeles
Orimoloye, Helen T. University of North Texas
Deng, Chuanjie University of California, Los Angeles
Hansen, Johnni Danish Cancer Society Research Center
Olsen, Jorn Aarhus University
Ritz, Beate University of California, Los Angeles
Janzen, Carla University of California, Los Angeles
Heck, Julia E. University of North Texas

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Springer Nature

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The College of Health and Public Service takes academics beyond the classroom and into the community through hands-on experience across a variety of social issues. The College includes seven academic departments along with centers and professional development and clinical training programs.

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Department: Epidemiology

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Article states that preeclampsia is a serious pregnancy complication that presents a significant risk to both the mother and the fetus. The authors examined the association between preeclampsia, antihypertensive medications, and childhood cancer in offspring.

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11 p.

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Abstract: Purpose: Preeclampsia is a serious pregnancy complication that presents a significant risk to both the mother and the fetus. Preeclampsia and medications associated with its treatment are potentially linked to increased childhood cancer risk. Therefore, we examined the association between preeclampsia, antihypertensive medications, and childhood cancer in offspring. Methods: Cases (n = 6,420) and controls (n = 160,484) were obtained from Danish national registries. We performed conditional logistic regression analyses to estimate the association between preeclampsia and childhood cancer risk, and examined the effects of antihypertensive medication use in pregnancy in relation to childhood cancer risk in the offspring with adjustment for relevant covariates. Results: We observed an increased risk of acute lymphoblastic leukemia (ALL) among those whose mothers had preeclampsia (OR = 1.36, 95% CI 1.03, 1.79), especially for severe preeclampsia (OR = 2.36, 95% CI 1.37, 4.08). We also estimated an increased cancer risk in children born to mothers who were prescribed diuretics during pregnancy [OR = 2.09, 95% confidence interval (CI) 1.39, 3.14]. Intake of other antihypertensive medications was not associated with childhood cancer (OR = 0.78, 95% CI 0.50, 1.23). Among women who did not take diuretics in pregnancy, preeclampsia was associated with neuroblastoma (OR = 2.22, 95% CI 1.08, 4.55). Conclusion: Our findings suggested an increased risk for certain types of cancer in the offspring of mothers with preeclampsia and an increased risk of cancer with diuretic intake during pregnancy.

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Cancer Causes & Control, 35, Springer Nature, August 3, 2023, pp. 1-11

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English

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Digital Object Identifier: https://doi.org/10.1007/s10552-023-01745-4
Accession or Local Control No: s10552-023-01745-4
Archival Resource Key: ark:/67531/metadc2288919

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Publication Title: Cancer Causes & Control
Volume: 35
Page Start: 43
Page End: 53
Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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August 3, 2023

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March 5, 2024, 2:23 p.m.

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March 13, 2024, 1:58 p.m.

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Askins, Lexie; Orimoloye, Helen T.; Deng, Chuanjie; Hansen, Johnni; Olsen, Jorn; Ritz, Beate et al. Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring, article, August 3, 2023; (https://digital.library.unt.edu/ark:/67531/metadc2288919/: accessed May 26, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Health and Public Service.

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