Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A population-based cohort study in Denmark

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Article describes how alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes. The authors investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD.

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Orimoloye, Helen T.; He, Di; Li, Tong; Janzen, Carla; Barjaktarevic, Igor; Wang, Xuexia et al. January 2, 2024.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by the UNT College of Health and Public Service to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 26 times, with 26 in the last month. More information about this article can be viewed below.

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Article describes how alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes. The authors investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD.

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14 p.

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Abstract: Background: Alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes. Objective: We investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD. Methods: Using a large cohort data of Danish mothers and children with AATD from 1973 to 2013 (n = 2,027,229), with 559 cases (305 mothers and 254 children). We conducted Poisson regression to examine associations between alpha-1 antitrypsin deficiency, adverse birth outcomes, and pregnancy complications in mothers and children. Results: AATD was related to term low birth weight [<2500g; Risk Ratio(RR) = 2.04, 95% confidence interval (CI): 1.50–2.79], lowest quartile of abdominal circumference at birth in children of non-smoking mothers (RR = 1.55, 95% CI: 1.14–2.11), delivery via Cesarean-section (RR = 1.59, 95% CI: 1.05–2.40), preterm birth (RR = 1.54, 95% CI: 1.19–2.00) and preeclampsia (RR = 2.64, 95% CI: 1.76–3.94). Conclusions: This emphasizes the need for mothers with AATD to be monitored closely during pregnancy to reduce the risk of adverse birth outcomes. Routine screening for alpha-1 antitrypsin in pregnancy may be considered among mothers with a pulmonary and liver disease history.

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  • PLOS ONE, 19(1), Public Library of Science, January 2, 2024, pp. 1-14

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  • Publication Title: PLOS ONE
  • Volume: 19
  • Issue: 1
  • Peer Reviewed: Yes

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  • January 2, 2024

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  • Feb. 28, 2024, 8:03 p.m.

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  • March 4, 2024, 12:14 p.m.

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Orimoloye, Helen T.; He, Di; Li, Tong; Janzen, Carla; Barjaktarevic, Igor; Wang, Xuexia et al. Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A population-based cohort study in Denmark, article, January 2, 2024; (https://digital.library.unt.edu/ark:/67531/metadc2288793/: accessed May 24, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Health and Public Service.

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