Electrophysiological Auditory Measures to Identify Potential Cortical Markers of Tinnitus

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Tinnitus, or the perception of sound in the absence of external acoustic stimuli, is a common condition that impacts approximately 10-15% of the United States population, with similar prevalence rates reported in other countries. Current diagnosis of tinnitus relies on case history and audiometric testing, which depend on responses provided by the patient. To date, there is no objective test that can be used for tinnitus diagnosis, despite the high prevalence and significant financial impacts of this condition. Cortical auditory evoked potentials have shown promise in their ability to assess not only the integrity of the auditory system, but also … continued below

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Caldwell, Joshua December 2022.

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Tinnitus, or the perception of sound in the absence of external acoustic stimuli, is a common condition that impacts approximately 10-15% of the United States population, with similar prevalence rates reported in other countries. Current diagnosis of tinnitus relies on case history and audiometric testing, which depend on responses provided by the patient. To date, there is no objective test that can be used for tinnitus diagnosis, despite the high prevalence and significant financial impacts of this condition. Cortical auditory evoked potentials have shown promise in their ability to assess not only the integrity of the auditory system, but also higher level preattentional and cognitive processing. For this study, the pitch-matched tinnitus frequency was used to evoke an auditory late response. Double oddball paradigms with the tinnitus frequency as the deviant stimuli were also used to evoke a mismatch negativity and P300 to determine where along the auditory pathway biomarkers of tinnitus may exist. The results of this study suggest that when the tinnitus frequency is incorporated into paradigms designed to produce cortical auditory evoked potentials, differences exist between participants with tinnitus and matched controls without tinnitus. Individuals with tinnitus exhibit smaller MMN amplitudes and area under the curve and have a more parietal distribution in their P300 responses on topographic maps compared to non-tinnitus participants. Evaluation of relationships between perceived tinnitus severity and electrophysiological measures also revealed that P2 latency was a significant predictor of tinnitus severity, with longer latencies indicating greater severity. Findings of this study have clinical implications for test paradigms that may be used in an objective tinnitus test battery and for measures that can predict tinnitus severity.

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  • December 2022

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  • Feb. 9, 2023, 4:59 p.m.

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Caldwell, Joshua. Electrophysiological Auditory Measures to Identify Potential Cortical Markers of Tinnitus, dissertation, December 2022; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc2048620/: accessed May 26, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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