Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel

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Study used in vitro tape stripping to evaluate efficacy of an anhydrous gel containing sertaconazole nitrate.

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14 p.

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Manian, Mahima; Madrasi, Kumpal & Chaturvedula, Ayyappa July 7, 2016.

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UNT Health Science Center is one of the nation's premier graduate academic medical centers, with five schools that specialize in patient-centered education, research, and health care: Texas College of Osteopathic Medicine, Graduate School of Biomedical Sciences, School of Public Health, School of Health Professions, and UNT System College of Pharmacy.

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Study used in vitro tape stripping to evaluate efficacy of an anhydrous gel containing sertaconazole nitrate.

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14 p.

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Abstract: Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen. In addition, it is important to determine the concentration of the drug in the skin in order to evaluate the subsequent efficacy and potential toxicity for topical formulations. For this purpose, an anhydrous gel containing sertaconazole nitrate as a model drug was formulated and the amount of the drug in the skin was determined by in vitro tape stripping. The apparent diffusivity and partition coefficients were then calculated by a mathematical model describing the dermal absorption as passive diffusion through a pseudo-homogenous membrane. The skin irritation potential of the formulation was also assessed by using the in vitro Epiderm™ model. An estimation of the dermal absorption parameters allowed us to evaluate drug transport across the stratum corneum following topical application. The estimated concentration for the formulation was found to be higher than the MIC100 at the target site which suggested its potential efficacy for treating fungal infections. The skin irritation test showed the formulation to be non-irritating in nature. Thus, in vitro techniques can be used for laying the groundwork in developing efficient and non-toxic topical products.

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  • Pharmaceutics, 8(3), Multidisciplinary Digital Publishing Institute, July 2016

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  • Volume: 8
  • Issue: 3
  • Pages: 14
  • Peer Reviewed: Yes
  • Publication Title: Pharmaceutics

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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  • July 7, 2016

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  • May 11, 2020, 3:41 p.m.

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  • Nov. 10, 2023, 12:35 p.m.

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Manian, Mahima; Madrasi, Kumpal & Chaturvedula, Ayyappa. Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel, article, July 7, 2016; [Basel, Switzerland]. (https://digital.library.unt.edu/ark:/67531/metadc1638172/: accessed May 29, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Health Science Center.

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