The Antimicrobial and Synergistic Efficiency of Antibiotic and Bacteriophage for the Treatment of Tuberculosis

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Paper describes a study exploring bacteriophages and antibiotics as a potential treatment for tuberculosis.

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26 p.: ill.

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Cai, Lucy 2014.

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This article is part of the collection entitled: The Eagle Feather and was provided by the UNT Honors College to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 63 times. More information about this article can be viewed below.

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Paper describes a study exploring bacteriophages and antibiotics as a potential treatment for tuberculosis.

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26 p.: ill.

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Abstract: Mycobacterium smegmatis mc2155 is a commonly used model organism for Mycobacterium tuberculosis, which is one of the most serious bacterial infections in the world. This study explored bacteriophages as potential treatment, and it was proposed that due to each agents’ distinct mechanisms of action, the synergy of antibiotic (isoniazid and ethambutol, separately), and bacteriophage would provide for more effective treatment than either agent alone in treating Mycobacterium smegmatis over time. Increasing concentrations of antibiotic were diluted with varying concentrations of lytic mycobacteriophage D29 and compared to the activity of the same varying concentrations of antibiotic and bacteriophage D29 alone on Mycobacterium smegmatis over time using absorbency values. While both agents only significantly treated the bacterial concentrations, bacteriophage in combination with ethambutol was significantly more effective than either agent alone, suggesting that the use of bacteriophage in combination with specific antibiotics should be explored further, especially for treating multi-drug resistant tuberculosis.

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  • Eagle Feather, Issue 11, University of North Texas Honors College: Denton, Texas. 2014

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  • Publication Title: Eagle Feather
  • Volume: 11
  • Issue: 2014
  • Peer Reviewed: Yes

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The Eagle Feather

Launched in 2004 by UNT's Honors College, The Eagle Feather was an interdisciplinary undergraduate research journal that promoted the work of students and their faculty mentors. The Eagle Feather was published annually until 2017 when it transitioned into the North Texas Journal of Undergraduate Research.

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This collection presents scholarly and artistic content created by undergraduate students. All materials have been previously accepted by a professional organization or approved by a faculty mentor. Most classroom assignments are not eligible for inclusion. The collection includes, but is not limited to Honors College theses, thesis supplemental files, professional presentations, articles, and posters. Some items in this collection are restricted to use by the UNT community.

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  • 2014

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  • March 9, 2020, 6:45 p.m.

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  • April 14, 2020, 6:15 p.m.

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Cai, Lucy. The Antimicrobial and Synergistic Efficiency of Antibiotic and Bacteriophage for the Treatment of Tuberculosis, article, 2014; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc1625021/: accessed May 24, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Honors College.

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