Tumor production in Syrian hamsters following inhalation of PuO/sub 2/--ZrO/sub 2/ aerosol

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Syrian golden hamsters of both sexes were exposed to aerosols of ZrO/sub 2/ containing PuO/sub 2/. The starting material in the aerosol generator also had a small amount of /sup 57/Co added as a tracer. The mixture of all three constituents was nebulized and the droplets passed through a heating column at 1000/sup 0/C. Aerosol sampling was accomplished with a cascade impactor and electrostatic precipitator. The median aerodynamic diameters in all inhalation runs were approximately 2 ..mu..m with a geometric standard deviation of 2. One exposed group of 60 hamsters had 6-day lung burdens averaging 100 nCi. This group had … continued below

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13 pages

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Thomas, R. G. & Smith, D. M. January 1, 1978.

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Syrian golden hamsters of both sexes were exposed to aerosols of ZrO/sub 2/ containing PuO/sub 2/. The starting material in the aerosol generator also had a small amount of /sup 57/Co added as a tracer. The mixture of all three constituents was nebulized and the droplets passed through a heating column at 1000/sup 0/C. Aerosol sampling was accomplished with a cascade impactor and electrostatic precipitator. The median aerodynamic diameters in all inhalation runs were approximately 2 ..mu..m with a geometric standard deviation of 2. One exposed group of 60 hamsters had 6-day lung burdens averaging 100 nCi. This group had a lung tumor incidence of 44% with an even distribution of adenomas and carcinomas. Two other groups had average 6-day lung burdens of 80 to 90 nCi plus 55 nCi of intravenously injected spheres localized in the lung. These animals had tumor incidences of approximately 30%.

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13 pages

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Dep. NTIS, PC A02/MF A01.

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  • ANS winter meeting, San Francisco, CA, USA, 27 Nov 1977

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  • Report No.: LA-UR-78-644
  • Report No.: CONF-771109-98
  • Grant Number: W-7405-ENG-36
  • Office of Scientific & Technical Information Report Number: 5111203
  • Archival Resource Key: ark:/67531/metadc1055322

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Office of Scientific & Technical Information Technical Reports

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  • January 1, 1978

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  • Jan. 22, 2018, 7:23 a.m.

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  • Jan. 8, 2021, 2:05 p.m.

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Thomas, R. G. & Smith, D. M. Tumor production in Syrian hamsters following inhalation of PuO/sub 2/--ZrO/sub 2/ aerosol, article, January 1, 1978; New Mexico. (https://digital.library.unt.edu/ark:/67531/metadc1055322/: accessed May 30, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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