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CYP1B1 expression, a potential risk factor for breast cancer

Description: CYP1B1 expression in non-tumor breast tissue from breast cancer patients and cancer-free individuals was determined to test the hypothesis that high CYP1B1 expression is a risk factor for breast cancer. Large interindividual variations in CYP1B1 expression were found with CYP1B1 levels notably higher in breast cancer patients than cancer-free individuals. The results indicate that CYP1B1 might play a role in breast cancer either through increased PAH activation or through metabolism of endogeno… more
Date: May 31, 2001
Creator: Goth-Goldstein, Regine; Erdmann, Christine A. & Russell, Marion
Partner: UNT Libraries Government Documents Department
open access

Combining loss of function of FOLYLPOLYGLUTAMATE SYNTHETASE1 and CAFFEOYL-COA 3-O-METHYLTRANSFERASE1 for lignin reduction and improved saccharification efficiency in Arabidopsis thaliana

Description: This article tests if lignin content can be further reduced by combining genetic mutations in C1 metabolism and the lignin biosynthetic pathway by generating and functionally characterizing fpgs1ccoaomt1 double mutants. The observations demonstrate that additional reduction in lignin content and improved sugar release can be achieved by simultaneous downregulation of a gene in the C1 (FPGS1) and lignin biosynthetic (CCOAOMT) pathways.
Date: May 3, 2019
Creator: Xie, Hongli; Engle, Nancy L.; Venketachalam, Sivasankari; Yoo, Chang Geun; Barros, Jaime; Lecoultre, Mitch et al.
Partner: UNT College of Science
open access

Combining loss of function of FOLYLPOLYGLUTAMATE SYNTHETASE1 and CAFFEOYL-COA 3-O-METHYLTRANSFERASE1 for lignin reduction and improved saccharification efficiency in Arabidopsis thaliana

Description: Article describes study in which fpgs1ccoaomt1 double mutants were generated and functionally characterized in order to test if lignin content can be further reduced by combining genetic mutations in C1 metabolism and the lignin biosynthetic pathway.
Date: May 3, 2019
Creator: Xie, Hongli; Engle, Nancy L.; Venketachalam, Sivasankari; Yoo, Chang Geun; Barros, Jaime; Lecoultre, Mitch et al.
Partner: UNT College of Science
open access

Visualization of a Deterministic Radiation Transport Model Using Standard Visualization Tools

Description: Output from a deterministic radiation transport code running on a CRAY SV1 is imported into a standard distributed, parallel, visualization tool for analysis. Standard output files, consisting of tetrahedral meshes, are imported to the visualization tool through the creation of a application specific plug-in module. Visualization samples are included, providing visualization of steady state results. Different plot types and operators are utilized to enhance the analysis and assist in reporting … more
Date: May 1, 2004
Creator: Galbraith, James A. & Greenwade, L. Eric
Partner: UNT Libraries Government Documents Department
open access

Sex-specific mitochondrial dynamics and mitophagy response to muscle damage

Description: Article presents a study examining the effect of sex-specific resistance exercise (RE)-induced hormonal response on mitochondrial dynamics and mitophagy after muscle damage in untrained men and women.
Date: May 25, 2022
Creator: Luk, Hui-Ying; Jiwan, Nigel C.; Appell, Casey R.; Levitt, Danielle E. & Vingren, Jakob L.
Partner: UNT College of Education
open access

Sensitivity Evaluation of the Daily Thermal Predictions of the AGR-1 Experiment in the Advanced Test Reactor

Description: A temperature sensitivity evaluation has been performed for the AGR-1 fuel experiment on an individual capsule. A series of cases were compared to a base case by varying different input parameters into the ABAQUS finite element thermal model. These input parameters were varied by ±10% to show the temperature sensitivity to each parameter. The most sensitive parameters are the outer control gap distance, heat rate in the fuel compacts, and neon gas fraction. Thermal conductivity of the compacts … more
Date: May 1, 2011
Creator: Hawkes, Grant; Sterbentz, James & Maki, John
Partner: UNT Libraries Government Documents Department
open access

Using synthetic biology to screen for functional diversity of GH1 enzymes

Description: Advances in next-generation sequencing technologies have enabled single genomes as well as complex environmental samples (metagenomes) to be comprehensively sequenced on a routine basis. Bioinformatics analysis of the resulting sequencing data reveals a continually expanding catalogue of predicted proteins ( 14 million as of April 2011), 75 percent of which are associated with functional annotation (COG, Pfam, Enzyme, Kegg, etc). These predicted proteins cover the full spectrum of known pathway… more
Date: May 31, 2011
Creator: Deutsch, Sam; Datta, Supratim; Hamilton, Matthew; Friedland, Greg; D'Haeseleer, Patrik; Chen, Jan-Fang et al.
Partner: UNT Libraries Government Documents Department
open access

User and Performance Impacts from Franklin Upgrades

Description: The NERSC flagship computer Cray XT4 system"Franklin" has gone through three major upgrades: quad core upgrade, CLE 2.1 upgrade, and IO upgrade, during the past year. In this paper, we will discuss the various aspects of the user impacts such as user access, user environment, and user issues etc from these upgrades. The performance impacts on the kernel benchmarks and selected application benchmarks will also be presented.
Date: May 10, 2009
Creator: He, Yun (Helen)
Partner: UNT Libraries Government Documents Department
open access

Application of a transverse phase-space measurement technique for high-brightness, H{sup {minus}} beams to the GTA H{sup {minus}} beam

Description: The Ground Test Accelerator (GTA) had the objective Of Producing a high-brightness, high-current H-beam. The major components were a 35 keV injector, a Radio Frequency Quadrupole (RFQ), an intertank matching section (IMS), and a drift tube linac (DTL), consisting of 10 modules. A technique for measuring the transverse phase-space of high-power density beams has been developed and tested. This diagnostic has been applied to the GTA H-beam. Experimental results are compared to the slit and collec… more
Date: May 1, 1995
Creator: Johnson, K. F.; Garcia, R. C.; Rusthoi, D. P.; Sander, O. R.; Sandoval, D. P.; Shinas, M. A. et al.
Partner: UNT Libraries Government Documents Department
open access

Radiative corrections for (e,e{prime}p) reactions at GeV energies

Description: A general framework for applying radiative corrections to (e,e{prime}p) coincidence reactions at GeV energies is presented, with special emphasis to higher-order Bremsstrahlung effects, radiation from the scattered hadron, and the validity of peaking approximations. The sensitivity to the assumptions made in practically applying radiative corrections to (e,e{prime}p) data is extensively discussed. The general framework is tested against experimental data of the {sup 1}H(e,e{prime}p) reaction at… more
Date: May 1, 2000
Creator: Ent, R.; Filippone, B. W.; Makins, N. C. R.; Milner, R. G.; O'Neill, T. G. & Wasson, D. A.
Partner: UNT Libraries Government Documents Department
open access

Phase-scan analysis results for the first drift tube linac module in the ground test accelerator: Data reproducibility and comparison to simulations

Description: The Ground Test Accelerator (GTA) had the objective of producing a high-brightness, high-current H- beam. The major accelerator components were a 35 keV injector, a Radio Frequency Quadrupole, an intertank matching section, and a drift tube linac (DTL), consisting of 10 modules. This paper discusses the phase-scan technique which was used to experimentally determine the rf operating parameters for the commissioning and routine operation of the first DTL module.
Date: May 1, 1995
Creator: Johnson, K. F.; Sander, O. R. & Bolme, G. O.
Partner: UNT Libraries Government Documents Department
open access

Insights into the structural function of the complex of HIV-1 protease with TMC-126: molecular dynamics simulations and free-energy calculations

Description: The binding properties of the protein-inhibitor complex of human immunodeficiency virus type 1 (HIV-1) protease with the inhibitor TMC-126 are investigated by combining computational alanine scanning (CAS) mutagenesis with binding free-energy decomposition (BFED). The calculated results demonstrate that the flap region (residues 38-58) and the active site region (residues 23-32) in HIV-1 protease contribute 63.72% of the protease to the binding of the inhibitor. In particular, the mechanisms fo… more
Date: May 1, 2012
Creator: Li, Dan; Han, Ju-Guang; Chen, Hang; Li, Liang; Zhao, Run-Ning Zhao; Liu, Guang et al.
Partner: UNT Libraries Government Documents Department
open access

Multicusp sources for ion beam lithography applications

Description: Application of the multicusp source for Ion Projection Lithography is described. It is shown that the longitudinal energy spread of the positive ions at the extraction aperture can be reduced by employing a magnetic filter. The advantages of using volume-produced H{sup {minus}} ions for ion beam lithography is also discussed.
Date: May 1, 1995
Creator: Leung, K. N.; Herz, P.; Kunkel, W. B.; Lee, Y.; Perkins, L.; Pickard, D. et al.
Partner: UNT Libraries Government Documents Department
open access

SPS Ecloud Instabilities - Analysis of Machine Studies and Implications for Ecloud Feedback

Description: The SPS at high intensities exhibits transverse single bunch instabilities with signatures consistent with an Ecloud driven instability. We present recent MD data from the SPS, details of the instrument technique and spectral analysis methods which help reveal complex vertical motion that develops within a subset of the injected bunch trains. The beam motion is detected via wideband exponential taper striplines and delta-sigma hybrids. The raw sum and difference data is sampled at 50 GHz with 1… more
Date: May 25, 2011
Creator: Fox, J.; Bullitt, A.; Mastorides, T.; Ndabashimiye, G.; Rivetta, C. H.; Turgut, O. et al.
Partner: UNT Libraries Government Documents Department
open access

Binding of the Respiratory Chain Inhibitor Antimycin to theMitochondrial bc1 Complex: A New Crystal Structure Reveals an AlteredIntramolecular Hydrogen-Bonding Pattern

Description: Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial respiratory chain, binds to the quinone reduction site of the cytochrome bc1 complex.Structure-activity-relationship studies have shown that the N-formylamino-salicyl-amide group is responsible for most of the binding specificity, and suggested that a low pKa for the phenolic OH group and an intramolecular H-bond between that OH and the carbonyl O of the salicylamide linkage are important. Two previo… more
Date: May 10, 2005
Creator: Huang, Li-shar; Cobessi, David; Tung, Eric Y. & Berry, Edward A.
Partner: UNT Libraries Government Documents Department
open access

Proliferation and Polarity in Breast Cancer: Untying the Gordian Knot

Description: Epithelial cancers are associated with genomic instability and alterations in signaling pathways that affect proliferation, apoptosis, and integrity of tissue structure. Overexpression of a number of oncogenic protein kinases has been shown to malignantly transform cells in culture and to cause tumors in vivo, but the interconnected signaling events induced by transformation still awaits detailed dissection. We propose that the network of cellular signaling pathways can be classified into funct… more
Date: May 9, 2005
Creator: Liu, Hong; Radisky, Derek C. & Bissell, Mina J.
Partner: UNT Libraries Government Documents Department
open access

Seismic response of a nuclear power generation complex including structure-to-structure interaction effects

Description: Seismic responses of the Zion nuclear power generation complex accounting for structure-to-structure interaction effects as predicted by CLASSI and FLUSH Codes are presented in this paper. Two aspects of the multi-structure analyses were considered: the effect of structure-to-structure interaction on structure response and the variability in structure response as predicted by different codes, including structure-to-structure interaction. The effect of structure- to-structure interaction on the … more
Date: May 2, 1997
Creator: Chen, J. C.; Masienikov, O. R. & Johnson, J. J.
Partner: UNT Libraries Government Documents Department
open access

Electronic excitation in transmission of relativistic H{sup {minus}} ions through thin foils

Description: The authors describe a theoretical model to study the transmission of relativistic H{sup {minus}} ions through thin carbon foils. The approach is based on a Monte Carlo solution of the Langevin equation describing electronic excitations of the atoms during the transport through the foil. Calculations for the subshell populations of outgoing hydrogen atoms are found to be in good agreement with recent experimental data on an absolute scale and show that there exists a propensity for populating e… more
Date: May 7, 1998
Creator: Reinhold, C.O.; Kuerpick, P.; Burgdoerfer, J.; Yoshida, S. & Gervais, B.
Partner: UNT Libraries Government Documents Department
open access

Lifetime test on a high-performance dc microwave proton source

Description: Powerful CW proton linear accelerators (100 mA at 0.5--1 GeV) are being proposed for spallation neutron source applications.These production accelerators require high availability and reliability. A microwave proton source, which has already demonstrated several key beam requirements, was operated for one week (170 hours) in a dc mode to test the reliability and lifetime of its plasma generator. The source was operated with 570 W of microwave (2.45 GHz) discharge power and with a 47-kV extracti… more
Date: May 1, 1995
Creator: Sherman, J. D.; Hodgkins, D. J.; Lara, P. D.; Schneider, J. D. & Stevens, R. R. Jr.
Partner: UNT Libraries Government Documents Department
open access

Experience With Polarized Proton Acceleration at Cosy (Julich)

Description: The Cooler Synchrotrons and storage ring COSY at the Forschungszentrum Juelich accelerates protons to momenta between 600 MeV/c and 3300 MeV/c [2]. At present the beam is used at four internal and three external target places. In addition, a polarized beam can be produced and accelerated at COSY. A colliding beams source, developed by a collaboration of the universities of Bonn, Erlangen, and Cologne is in operation [3]. The polarized H{sup {minus}} beam delivered by this source is pre-accelera… more
Date: May 20, 1999
Creator: Lehrach, A.
Partner: UNT Libraries Government Documents Department
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