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The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50

Description: The BARD1 N-terminal RING domain binds BRCA1 while the BARD1 C-terminal ankyrin and tandem BRCT repeat domains bind CstF-50 to modulate mRNA processing and RNAP II stability in response to DNA damage. Here we characterize the BARD1 structural biochemistry responsible for CstF- 50 binding. The crystal structure of the BARD1 BRCT domain uncovers a degenerate phosphopeptide binding pocket lacking the key arginine required for phosphopeptide interactions in other BRCT proteins.Small angle X-ray sca… more
Date: July 13, 2009
Creator: Edwards, Ross A.; Lee, Megan S.; Tsutakawa, Susan E.; Williams, R. Scott; Tainer, John A. & Glover, J. N. Mark
Partner: UNT Libraries Government Documents Department
open access

The New Minimal Standard Model

Description: We construct the New Minimal Standard Model that incorporates the new discoveries of physics beyond the Minimal Standard Model (MSM): Dark Energy, non-baryonic Dark Matter, neutrino masses, as well as baryon asymmetry and cosmic inflation, adopting the principle of minimal particle content and the most general renormalizable Lagrangian. We base the model purely on empirical facts rather than aesthetics. We need only six new degrees of freedom beyond the MSM. It is free from excessive flavor-cha… more
Date: January 13, 2005
Creator: Davoudiasl, Hooman; Kitano, Ryuichiro; Li, Tianjun & Murayama, Hitoshi
Partner: UNT Libraries Government Documents Department
open access

The DEEP2 Galaxy Redshift Survey: AEGIS observations of a Dual AGNat z = 0.7

Description: We present evidence for a dual Active Galactic Nucleus (AGN) within an early-type galaxy at z = 0.709 in the Extended Groth Strip. The galaxy lies on the red sequence, with absolute magnitude M{sub B} = -21.0 ( AB, w , with h = 0 0.7) and rest-frame color U - B = 1.38. Its optical spectrum shows strong, double-peaked [O III] emission lines and weak H{beta} emission, with Seyfert-like line ratios. The two narrow peaks are separate by 630 km s-1 in velocity and arise from two distinct regions, sp… more
Date: October 13, 2006
Creator: Gerke1, Brian F.; Newman, Jeffrey A.; Lotz, Jennifer; Yan,Renbin; Barmby, P.; Coil, Alison L. et al.
Partner: UNT Libraries Government Documents Department
open access

1-watt composite-slab Er:YAG laser. Revision 1

Description: A diode-side-pumped discrete-optic Er{sup 3+} :YAG laser employs pump-light coupling through a sapphire plate diffusion-bonded to the laser slab, removing heat directly at the pump face of the slab instead of requiring conduction through to its far side. This lowers the temperature in the gain region and gives reduced thermal lensing, which produces exceptional beam quality (M{sup 2} {approx} 1.3) at output powers {approx} 0.3 Watt. Powers above 1 Watt have been demonstrated with peak slope eff… more
Date: February 13, 1997
Creator: Page, R. H.; Bartels, R. A.; Beach, R. J.; Sutton, S. B.; Furu, L. H. & LaSala, J. E.
Partner: UNT Libraries Government Documents Department
open access

Design and Formation of a Large, Tetrahedral, Metal-ligand Cluster Using 1,1'-Binaphthyl Ligands

Description: Many chemists have been fascinated with the development of discrete supramolecular structures that encapsulate guest molecules. These structures can be assembled through covalent or hydrogen bonds, electrostatic or metal-ligand interactions. These host structures have provided valuable insight into the forces involved in small molecule recognition. Our work has focused on the design and study of metal-ligand clusters of varying sizes. The naphthalene [M{sub 4}L{sub 6}]{sup 12-} cluster 1, shown… more
Date: March 13, 2008
Creator: Biros, Shannon M.; Yeh, Robert M. & Raymond, Kenneth N.
Partner: UNT Libraries Government Documents Department
open access

The Effect of UDP-glucuronosyltransferase 1A1 Expression on the Mutagenicity and Metabolism of the Cooked-Food Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4-5,b]pyridine in CHO cells

Description: UDP-glucuronosyltransferase proteins (UGT) catalyze the glucuronidation of both endogenous and xenobiotic compounds. In previous studies UGT1A1 has been implicated in the detoxification of certain food-borne-carcinogenic-heterocyclic amines. To determine the importance of UDP-glucuronosyltransferase 1A1 (UGT1A1) in the biotransformation of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), genetically modified CHO cells that are nucleotide excision repair-deficie… more
Date: August 13, 2004
Creator: Malfatti, M A; Wu, R W & Felton, J S
Partner: UNT Libraries Government Documents Department
open access

Update of Run 1 b results at CDF

Description: While the Collider Detector at Fermilab (CDF) is starting a new data run, it is also finishing analyses based on the 100 pb{sup -1} ''Run 1'' data sample collected between 1992 and 1996. In particular, the {Lambda}{sub b} lifetime has been measured using the exclusive decay channel {Lambda}{sub b} {yields} J/{psi}{Lambda}{sup 0}. The B{sup +} cross section, based upon the decay B{sup +} {yields} J/{psi}K{sup +}, has been finalized, as well as the ratio of inclusive b quark cross sections at {ra… more
Date: August 13, 2002
Creator: Tseng, J.
Partner: UNT Libraries Government Documents Department
open access

Prospects for generating 1-10 TPa pressures with a railgun

Description: It has been demonstrated that a plasma arc can be accelerated along two current carrying parallel rails and used to accelerate a projectile. We have performed an extensive analysis and found the task of using a railgun to accelerate an impactor plate to velocities of 10 to 40 km/s to be feasible with contemporary technology. This range of impact velocities would enable shock pressures of 1 to 10 TPa to be generated for EOS research.
Date: July 13, 1979
Creator: Hawke, R. S. & Scudder, J. K.
Partner: UNT Libraries Government Documents Department
open access

Biosynthesis of the Cyclotide Kalata B1 using a Protein Splicing Unit

Description: Cyclotides are a newly emerging family of large backbone cyclic polypeptides ({approx}30 residues long) characterized by a disulfide-stabilized core (3 disulfide bonds) with an unusual knotted structure. In contrast to other cyclic polypeptides, cyclotides have a well-defined three-dimensional structure. Therefore, despite their small size, they can be considered miniproteins. The unique cyclic-backbone topology and knotted arrangement of 3 disulfide bonds endow cyclotides with exceptional stab… more
Date: August 13, 2005
Creator: Kimura, R H; Tran, A T & Camarero, J A
Partner: UNT Libraries Government Documents Department
open access

Biosynthesis of the cyclotide Kalata B1 using protein splicing tools

Description: Cyclotides are a new emerging family of large cyclic polypeptides ({approx}30 residues long) that share a disulfide-stabilized core (3 disulfide bonds) with an unusual knotted structure (Fig. 1A) [1]. Cyclotides contrast with other circular polypeptides in that they have a highly defined three-dimensional structure, and despite their small size, can be considered as miniproteins. Their unique circular backbone topology and knotted arrangement of 3 disulfide bonds makes them exceptionally stable… more
Date: July 13, 2005
Creator: Kimura, R.; Krishnan, K. & Camarero, J. A.
Partner: UNT Libraries Government Documents Department
open access

Hydrogen peroxide propulsion for smaller satellites (SSC98-VIII-1)

Description: As satellite designs shrink, providing maneuvering and control capability falls outside the realm of available propulsion technology. While cold gas has been used on the smallest satellites, hydrogen peroxide propellant is suggested as the next step in performance and cost before hydrazine. Minimal toxicity and a small scale enable benchtop propellant preparation and development testing. Progress toward low-cost thrusters and self-pressurizing tank systems is described.
Date: July 13, 1998
Creator: Whitehead, J. C.
Partner: UNT Libraries Government Documents Department
open access

[1/2 HP Maytag Restoration]

Description: Article by Pettinger, Wesley E. about 1/2 HP Maytag Engine Restoration.
Date: January 13, 1997
Creator: Pettinger, Wesley E.
Partner: UNT Libraries Special Collections
open access

Parameter studies of candidate lattices for the 1-2 GeV synchrotron radiation source

Description: This document discusses the implications of various collective phenomena on the required performance of candidate lattices for the LBL 1 to 2 GeV Synchrotron Radiation Source. The performance issues considered include bunch length, emittance growth, and beam lifetime. In addition, the possible use of the 1 to 2 GeV Synchrotron Radiation Source as a high-gain FEL is explored briefly. Generally, the differences between lattices are minor. It appears that the most significant feature distinguishin… more
Date: January 13, 1986
Creator: Zisman, M. S.
Partner: UNT Libraries Government Documents Department
open access

Allele-specific deposition of macroH2A1 in Imprinting Control Regions

Description: In the current study, we analyzed the deposition patterns of macroH2A1 at a number of different genomic loci located in X chromosome and autosomes. MacroH2A1 is preferentially deposited at methylated CpG CpG-rich regions located close to promoters. The macroH2A1 deposition patterns at the methylated CpG islands of several imprinted domains, including the Imprinting Control Regions (ICRs) of Xist, Peg3, H19/Igf2 Igf2, Gtl2/Dlk1, and Gnas domains, show consistent allele-specificity towards inacti… more
Date: January 13, 2006
Creator: Choo, J H; Kim, J D; Chung, J H; Stubbs, L & Kim, J
Partner: UNT Libraries Government Documents Department
open access

Risk from a compressed toxic gas system: Part 1, Dispersal probability

Description: At the Lawrence Livermore National Laboratory, we have prepared a Safety Analysis Report for the Department of Energy on our Building 332 Plutonium Handling Facility. This SAR includes an analysis of potential accident scenarios which could lead to offsite consequences to the public having not only radiological exposures, but also exposures to toxic gases such as chlorine. This paper presents a risk analysis of pressurized chlorine gas system proposed for use at Building 332. The focus of the a… more
Date: February 13, 1995
Creator: Altenbach, T.J. & Brereton, S.J.
Partner: UNT Libraries Government Documents Department
open access

Magnetic Anticrossing of 1D Subbands in Coupled Ballistic Double Quantum Wires

Description: We study the low-temperature in-plane magnetoconductance of vertically coupled double quantum wires. Using a novel flip-chip technique, the wires are defined by two pairs of mutually aligned split gates on opposite sides of a s 1 micron thick AlGaAs/GaAs double quantum well heterostructure. We observe quantized conductance steps due to each quantum well and demonstrate independent control of each ID wire. A broad dip in the magnetoconductance at -6 T is observed when a magnetic field is applied… more
Date: July 13, 2000
Creator: Blount, Mark A.; Moon, Jeong-Sun; Simmons, Jerry A.; Lyo, Sungkwun K.; Wendt, Joel R. & Reno, John L.
Partner: UNT Libraries Government Documents Department
open access

Exploring New Active Regions for Type 1 InasSb Strained-Layer Lasers

Description: We report on the metal-organic chemical vapor deposition (MOCVD) of mid- infrared InAsSb/InPSb optically pumped lasers grown using a high speed rotating disk reactor (RDR). The devices contain AlAsSb claddings and strained, type 1, InAsSb/InPSb active regions. By changing the layer thickness and composition of InAsSb/InPSb SLSs, we have prepared structures with low temperature (<20K) photoluminescence wavelengths ranging from 3.4 to 4.8 &micro;m. We find a variation of bandgap from 0.272 to 0.3… more
Date: May 13, 1999
Creator: Biefeld, R. M.; Kurtz, S. R. & Phillips, J. D.
Partner: UNT Libraries Government Documents Department
open access

Dynamics of Exchange at Gas-Zeolite Interfaces 1: Pure Component n-Butane and Isobutane

Description: The authors present the results of molecular dynamics simulations of n-butane and isobutane in silicalite. They begin with a comparison of the bulk adsorption and diffusion properties for two different parameterizations of the interaction potential between the hydrocarbon species, both of which have been shown to reproduce experimental gas-liquid coexistence curves. They examine diffusion as a function of the loading of the zeolite, as well as the temperature dependence of the diffusion constan… more
Date: July 13, 2000
Creator: Chandross, Michael E.; Webb, Edmund B., III; Grest, Gary S.; Martin, Marcus G.; Thompson, Aidan P. & Roth, M. W.
Partner: UNT Libraries Government Documents Department
open access

SATB1 tethers multiple gene loci to reprogram expression profiledriving breast cancer metastasis

Description: Global changes in gene expression occur during tumor progression, as indicated by expression profiling of metastatic tumors. How this occurs is poorly understood. SATB1 functions as a genome organizer by folding chromatin via tethering multiple genomic loci and recruiting chromatin remodeling enzymes to regulate chromatin structure and expression of a large number of genes. Here we show that SATB1 is expressed at high levels in aggressive breast cancer cells, and is undetectable in non-malignan… more
Date: July 13, 2006
Creator: Han, Hye-Jung; Kohwi, Yoshinori & Kohwi-Shigematsu, Terumi
Partner: UNT Libraries Government Documents Department
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