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A gene based approach to test genetic association based on an optimally weighted combination of multiple traits

In this article, the authors propose a statistical method by Testing an Optimally Weighted Combination of Multiple traits (TOW-CM) to test the association between multiple traits and multiple variants in a genomic region (a gene or pathway). They investigate the performance of the proposed method through extensive simulation studies. Their simulation studies show that the proposed method has correct type I error rates and is either the most powerful test or comparable with the most powerful tes… more

Date: August 9, 2019

Creator: Zhang, Jianjun; Sha, Qiuying; Liu, Guanfu & Wang, Xuexia

Item Type: Article

Partner: UNT College of Science

open access

Correlation consistent basis sets designed for density functional theory: Second-row (Al-Ar)

Article presenting cc-pV(n+d)Z correlation consistent basis sets of double- through quintuple-ζ quality for the atoms Al-Ar that have been modified for use with density functional theory (DFT). These basis set modifications include truncation of high-angular momentum basis functions, recontraction of the s- and p-functions, and reoptimization of basis function exponents with generalized gradient approximation and hybrid-DFT functionals. The effects of basis set truncation, recontraction, and re… more