Radiolabeled androgens and progestins as imaging agents for tumors of the prostate and breast
Description:
We are preparing progestins and androgens, labeled with the single photon emitters technetium-99m and rhenium-186 and the positron-emitting radionuclide fluorine-18. In both cases, ligands selected have very high affinity for the respective receptor, low affinity for blood and non-specific binders and to be reasonably resistant to metabolism: The progestins will be derivatives of the potent progestins ORG2058, norgestrel, RU486, and an unusual retroprogestin and the androgens will be derivative…
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Date:
August 8, 1992
Creator:
Katzenellenbogen, J.A.
Item Type:
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Partner:
UNT Libraries Government Documents Department