Electrospray mass spectrometry of NeuAc oligomers associated with the C fragment of the tetanus toxin
Description:
The Clostridial neurotoxins, botulinum and tetanus, gain entry into neuronal cells by protein recognition involving cell specific binding sites. The sialic or N-acetylneuraminic acid (NeuAc) residues of gangliosides attached to the surface of motor neurons are the suspected recognition and interaction points with Clostridial neurotoxins, although not necessarily the only ones. We have used electrospray ionization mass spectrometry (ESIMS) to examine formation of complexes between the tetanus to…
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Date:
April 3, 2005
Creator:
Prieto, M C; Whittal, R M; Baldwin, M A; Burlingame, A L & Balhorn, R
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UNT Libraries Government Documents Department