New prodrugs based on phospholipid-nucleoside conjugates
Description:
A method is described for the preparation of defined, isomerically pure phospholipid-nucleoside conjugates as a prodrug in which the drug (araC) is attached to the phospholipid by a monophosphate linkage. Key intermediates in the process involve selective blocking and deblocking of the nucleoside derivative. These particular monophosphate-linked derivatives represent a new class of prodrug, which are useful by themselves or in combination with diphosphate linked derivatives. Several new composi…
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Date:
February 3, 1982
Creator:
MacCoss, M.
Item Type:
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Patent
Partner:
UNT Libraries Government Documents Department