452 Matching Results

Search Results

Results: 1 - 24 next
open access

Impact of a Genetically Engineered Probiotic Therapy and IGF-1 Genomics in the PAHenu2 Mouse Model of PKU

Description: Absence of functional phenylalanine hydroxylase results in phenylketonuria (PKU). Viable treatments remain few, expensive and secondary conditions such as osteopenia occur in most PKU patients. Objective 1: Given the recently described roles of gut microbes to aid host digestion, an orally administered genetically engineered probiotic as the delivery vehicle for enzyme replacement therapy was created. The engineered probiotic, pHENOMMenal, produced phenylalanine ammonia lyase with significant… more
Date: December 2015
Creator: Durrer, Katherine Elaine
Partner: UNT Libraries
open access

Processing and Characterization of Polycarbonate Foams with Supercritical Co2 and 5-Phenyl-1H-tetrazole

Description: Since their discovery in the 1930s, polymeric foams have been widely used in the industry for a variety of applications such as acoustical and thermal insulation, filters, absorbents etc. The reason for this ascending trend can be attributed to factors such as cost, ease of processing and a high strength to weight ratio compared to non-foamed polymers. The purpose of this project was to develop an “indestructible” material made of polycarbonate (PC) for industrial applications. Due to the high … more
Date: May 2015
Creator: Cloarec, Thomas
Partner: UNT Libraries
open access

Effect of Acute Alcohol Ingestion on Resistance Exercise Induced mTORC1 Signaling in Human Muscle

Description: The purpose of this project was to further elucidate the effects post-exercise alcohol ingestion. This project had many novel aspects including using a resistance exercise (RE) only exercise design and the inclusion of women. To our knowledge, we are the first to investigate the effect of post-RE alcohol ingestion in women. In the first chapter of this project, information on the prevalence of alcohol use and the importance of skeletal muscle as a dynamic and metabolic tissue was provided. In c… more
Date: August 2015
Creator: Duplanty, Anthony A.
Partner: UNT Libraries
open access

Forward Genetic Characterization of Medicago truncatula Tnt1 Insertion Mutants Defective in Nodule Development and Symbiotic Nitrogen Fixation

Description: Legumes are unique plants because they form special structures “nodules”, via symbiotic relationships with rhizobial bacteria present in the soil. Once rhizobia mature inside nodules, they fix atmospheric nitrogen providing a source of bioavailable nitrogen to the plant. To discover novel genetic components involved in the legume-rhizobia symbiosis by using forward genetic screening, we have isolated Medicago truncatula Tnt1 insertion mutants in the R108 ecotype, which are defective in nodule d… more
Date: May 2015
Creator: Kadel, Khem L.
Partner: UNT Libraries
open access

Bass Reeves: a History • a Novel • a Crusade, Volume 1: the Rise

Description: This literary/historical novel details the life of African-American Deputy US Marshal Bass Reeves between the years 1838-1862 and 1883-1884. One plotline depicts Reeves’s youth as a slave, including his service as a body servant to a Confederate cavalry officer during the Civil War. Another plotline depicts him years later, after Emancipation, at the height of his deputy career, when he has become the most feared, most successful lawman in Indian Territory, the largest federal jurisdiction in A… more
Date: August 2015
Creator: Thompson, Sidney, 1965-
Partner: UNT Libraries
open access

Let Her Be Shorn: 1 Corinthians 11 and Female Head Shaving in Antiquity

Description: In 1 Corinthians 11:3-15, Paul writes that if a woman is to be so immodest as to wear her hair uncovered while praying or prophesying in a Christian assembly she might as well shave her head. Paul instructs the Corinthians that it is “one and the same” for a woman to have her head shaved and for her to unveil her hair. There is a large body of works cataloging the modesty standards in Hellenistic Greece but Paul’s reference to head-shaving remains obscure. This thesis looks to find the best exp… more
Date: December 2015
Creator: Montier, Curtis E.
Partner: UNT Libraries
open access

A High-fat Meal Alters Post-prandial mRNA Expression of SIRT1, SIRT4, and SIRT6

Description: Sirtuins (SIRT) regulate the transcription of various genes involved in the development of diet-induced obesity and chronic disease; however, it is unknown how they change acutely following a high-fat meal. The purpose of this study was to determine the effect of a high-fat meal (65% kcals/d; 85% fat recommendation), on SIRT1-7 mRNA expression in blood leukocytes at 1, 3, and 5-h post-prandial. Men and women (N=24) reported to the lab following an overnight fast (>12H). Total RNA was isolated a… more
Date: December 2015
Creator: Best Sampson, Jill Nicole
Partner: UNT Libraries
open access

Identification of Genes Involved in Flocculation by Whole Genome Sequencing of Thauera aminoaromatica Strain MZ1T Floc-defective Mutants

Description: Thauera aminoaromatica MZ1T, a floc-forming bacterium isolated from an industrial activated sludge wastewater treatment plant, overproduces exopolysaccharide (EPS) leading to viscous bulking. This phenomenon results in poor sludge settling and dewatering during the clarification process. To identify genes responsible for bacterial flocculation, a whole genome phenotypic sequencing technique was applied. Genomic DNA of MZ1T flocculation-deficient mutants were subjected to massively parallel sequ… more
Date: December 2015
Creator: Prombutara, Pinidphon
Partner: UNT Libraries
open access

Deleterious Synergistic Effects of Concurrent Magnetic Field and Superparamagnetic (Fe3O4) Nanoparticle Exposures on CHO-K1 Cell Line

Description: While many investigations have been performed to establish a better understanding of the effects that magnetic fields and nanoparticles have on cells, the fundamental mechanisms behind the interactions are still yet unknown, and investigations on concurrent exposure are quite limited in scope. This study was therefore established to investigate the biological impact of concurrent exposure to magnetic nanoparticles and extremely-low frequency magnetic fields using an in-vitro CHO-K1 cell line mo… more
Date: May 2015
Creator: Coker, Zachary
Partner: UNT Libraries
open access

Effect of Friction-stir Processing on the Wear Behavior of Titanium (Ti-1Al-8V-5Fe) and Stainless Steel (A-286) Alloys

Description: The effect of friction stir processing (FSP) on the mechanical wear behavior was investigated for Ti-1Al-8V-5Fe (Ti-185) and stainless steel (Incoloy® A-286) alloys. The Ti-185 and A-286 alloys were tested in different processing conditions, including as rolled (AR), AR+FSP, and AR+FSP+aged. A high frequency reciprocating rig was used to simulate fretting-type wear of these alloys at room temperature. The Vickers micro-hardness and wear rates were calculated and compared for each processing co… more
Date: May 2015
Creator: Tinubu, Olusegun Olukunle
Partner: UNT Libraries
open access

Variational Calculations of Positronium Scattering with Hydrogen

Description: Positronium-hydrogen (Ps-H) scattering is of interest, as it is a fundamental four-body Coulomb problem. We have investigated low-energy Ps-H scattering below the Ps(n=2) excitation threshold using the Kohn variational method and variants of the method with a trial wavefunction that includes highly correlated Hylleraas-type short-range terms. We give an elegant formalism that combines all Kohn-type variational methods into a single form. Along with this, we have also developed a general formali… more
Date: December 2015
Creator: Woods, Denton
Partner: UNT Libraries
open access

Dual-Band Quarter Wavelength and Half Wavelength Microstrip Transmission Line Design

Description: The thesis represents the design for dual-band quarter wavelength and half wavelength microstrip transmission line. Chapter 2 proposed the design of a novel dual-band asymmetric pi-shaped short-circuited quarter wavelength microstrip transmission line working at frequencies 1GHz and 1.55 GHz for 50Ω transmission line and at frequencies 1GHz and 1.43GHz for 60Ω transmission line. Chapter 3 proposed the design of a novel dual-band quarter wavelength microstrip transmission line with asymmetricall… more
Date: May 2015
Creator: Imran, Md Asheque
Partner: UNT Libraries
open access

Determination of Solute Descriptors for Illicit Drugs Using Gas Chromatographic Retention Data and Abraham Solvation Model

Description: In this experiment, more than one hundred volatile organic compounds were analyzed with the gas chromatograph. Six capillary columns ZB wax plus, ZB 35, TR1MS, TR5, TG5MS and TG1301MS with different polarities have been used for separation of compounds and illicit drugs. The Abraham solvation model has five solute descriptors. The solute descriptors are E, S, A, B, L (or V). Based on the six stationary phases, six equations were constructed as a training set for each of the six columns. The si… more
Date: August 2015
Creator: Mitheo, Yannick K.
Partner: UNT Libraries
open access

Identification and Characterization of an Arabidopsis thaliana Mutant with Tolerance to N-lauroylethanolamine

Description: N-Acylethanolamines (NAEs) are fatty acid derivatives in plants that negatively influence seedling growth. N-Lauroylethanolamine (NAE 12:0), one type of NAE, inhibits root length, increases radial swelling of root tips and reduces root hair numbers in a dose dependent manner in Arabidopis thaliana L. (ecotype Columbia). A forward genetics approach was employed by screening a population of T-DNA “activation-tagged” developed by the Salk Institute lines for NAE resistance to identify potential … more
Date: December 2015
Creator: Adhikari, Bikash
Partner: UNT Libraries
open access

Application of the Correlation Consistent Composite Approach to Biological Systems and Noncovalent Interactions

Description: Advances in computing capabilities have facilitated the application of quantum mechanical methods to increasingly larger and more complex chemical systems, including weakly interacting and biologically relevant species. One such ab initio-based composite methodology, the correlation consistent composite approach (ccCA), has been shown to be reliable for the prediction of enthalpies of formation and reaction energies of main group species in the gas phase to within 1 kcal mol-1, on average, of w… more
Date: May 2015
Creator: Riojas, Amanda G.
Partner: UNT Libraries
open access

The Effect of Post-resistance Exercise Alcohol Ingestion on LPS-stimulated Cytokines

Description: The purpose of this study was to examine the effect of post-resistance exercise alcohol ingestion on LPS-stimulated production of IFNγ, TNF-α, IL-1β, IL-6, IL-8, and IL-10. Recreationally resistance-trained men (n = 10, 25 ± 3 yr, 177 ± 7 cm, 83.8 ± 15.7 kg, 14.8 ± 8.5% body fat) and women (n = 8, 23 ± 2 yr, 161 ± 3 cm, 59.5 ± 6.0 kg, 26.5 ± 3.0% body fat) completed the study. Participants visited the laboratory for an initial visit at which time they were screened, familiarized with procedures… more
Date: August 2015
Creator: Levitt, Danielle E.
Partner: UNT Libraries
open access

Optimal Strategies for Stopping Near the Top of a Sequence

Description: In Chapter 1 the classical secretary problem is introduced. Chapters 2 and 3 are variations of this problem. Chapter 2, discusses the problem of maximizing the probability of stopping with one of the two highest values in a Bernoulli random walk with arbitrary parameter p and finite time horizon n. The optimal strategy (continue or stop) depends on a sequence of threshold values (critical probabilities) which has an oscillating pattern. Several properties of this sequence have been proved by Dr… more
Date: December 2015
Creator: Islas Anguiano, Jose Angel
Partner: UNT Libraries
open access

Longitudinal Prevalence of Disordered Eating and Weight Control Behaviors in Female Collegiate Athletes

Description: Female collegiate athletes have been established as a high-risk group for the development of eating disorders due to the high prevalence rates of clinical and subclinical eating disorders, which have ranged from 1.9% to 16.6% and 4.0% to 26.1%, respectively. Collegiate athletes appear to meet criteria for ED-NOS more often than anorexia or bulimia nervosa, and frequently engage in pathogenic weight control behaviors (e.g., dieting, excessive exercise). To date, only a few studies have examined … more
Date: December 2015
Creator: Thompson, Alexandra J.
Partner: UNT Libraries
open access

Synthesis of Peropyrene and Tetracene Derivatives for Photochemical Applications

Description: A novel route for the synthesis of the polycyclic aromatic hydrocarbon peropyrene (Pp) is reported along with the efforts to synthesize derivatives of Pp, 2,2′- and 5,5′-linked tetracene dimers as candidates for study as singlet fission materials in photovoltaic devices. Peropyrene was synthesized by the McMurry coupling conditions from phenalenone and low-valent titanium species. The crystal structure of Pp is formed by π-stacked molecular pairs in a herringbone arrangement. The direct functio… more
Date: May 2015
Creator: Rodríguez López, Marco Tulio
Partner: UNT Libraries
open access

A Precise Few-nucleon Size Difference by Isotope Shift Measurements of Helium

Description: We perform high precision measurements of an isotope shift between the two stable isotopes of helium. We use laser excitation of the 2^3 S_1-2^3 P_0 transition at 1083 nm in a metastable beam of 3He and 4He atoms. A newly developed tunable laser frequency selector along with our previous electro-optic frequency modulation technique provides extremely reliable, adaptable, and precise frequency and intensity control. The intensity control contributes negligibly to overall experimental uncertai… more
Date: August 2015
Creator: Hassan Rezaeian, Nima
Partner: UNT Libraries
open access

Thin Films As a Platform for Understanding the Conversion Mechanism of FeF2 Cathodes in Lithium-Ion Microbatteries

Description: Conversion material electrodes such as FeF2 possess the potential to deliver transformative improvements in lithium ion battery performance because they permit a reversible change of more than one Li-ion per 3d metal cation. They outperform current state of the art intercalation cathodes such as LiCoO2, which have volumetric and gravimetric energy densities that are intrinsically limited by single electron transfer. Current studies focus on composite electrodes that are formed by mixing with ca… more
Date: August 2015
Creator: Santos-Ortiz, Reinaldo
Partner: UNT Libraries
open access

Cognitive Performance as a Function of Sleep Disturbance in the Postpartum Period

Description: New mothers often complain of impaired cognitive functioning, and it is well documented that women experience a significant increase in sleep disturbance after the birth of a child. Sleep disturbance has been linked to impaired cognitive performance in several populations, including commercial truck drivers, airline pilots, and medical residents, though this relationship has rarely been studied in postpartum women. In the present study 13 pregnant women and a group of 22 non-pregnant controls c… more
Date: August 2015
Creator: Wilkerson, Allison K.
Partner: UNT Libraries
open access

The Effects of a Psychosocial Environment on College Women’s Exercise Regulations and Social Physique Anxiety

Description: A positive psychosocial intervention comprised of high autonomy support, task-involvement, and caring was implemented in physical activity classes to examine its effects on college women’s basic psychological needs (i.e. autonomy, competence, relatedness), exercise regulations (i.e. external, introjected, identified, integrated, intrinsic) and social physique anxiety (SPA). We hypothesized that at the end of the semester, participants in the intervention group (N = 73) would report greater need… more
Date: May 2015
Creator: Alvarez, Ana
Partner: UNT Libraries
open access

Genetic Analysis of Medicago truncatula Plants with a Defective MtIRE Gene

Description: Leguminous plants are able to fix nitrogen by establishing a symbiotic relationship with soil dwelling bacteria, called rhizobia. The model plant Medicago truncatula forms a partnership with Sinorhizobium meliloti whereby the plant gains bioavailable nitrogen and in exchange the bacteria gains carbohydrates. This process occurs within nodules, which are structures produced on the roots of the plants within which nitrogen is fixed. M. truncatula incomplete root elongation (MtIRE) was localized t… more
Date: August 2015
Creator: Alexis, Naudin
Partner: UNT Libraries
Back to Top of Screen