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A Forensic Marker for a Genetic Disease Often Misdiagnosed as Sudden Infant Death Syndrome (SIDS)

Description: Sudden Infant Death (SIDS) has been associated with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid oxidation. Blood and tissue samples from a large cohort of SIDS victims were analyzed for the presence of dodecanoic acid (C₁₂) by gas chromatography. A subgroup of these cases had a significantly higher blood concentration than age-matched controls, suggesting MCAD deficiency. An animal study using Sprague-Dawley rats was done to mimic the effects of MCAD def… more
Date: December 1991
Creator: Kemp, Philip M. (Philip Marcus)
Partner: UNT Libraries
open access

Cardiovascular and Hormonal Responses to Orthostasis Following Four Hours of Head-Down Rest in Endurance-Exercise-Trained and Untrained Subjects

Description: Cardiovascular and hormonal responses to +700 head-up tilt (HUT: orthostatic challenge) were compared between six endurance exercise trained (ET) and six untrained (UT) subjects prior to and immediately following 4 hours of -60 head-down rest (HDR). The ET subjects showed a significant (P < 0.05) decrease in orthostatic tolerance time (pre syncopal symptoms) during post-HDR HUT, while no difference was observed between ET and UT groups in pre-HDR HUT. The volume regulatory hormonal responses we… more
Date: December 1990
Creator: Chen, Jia-Jen
Partner: UNT Libraries
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