Autophosphorylation and Autoactivation of an S6/H4 Kinase Isolated From Human Placenta
Description:
A number of protein kinases have been shown to undergo autophosphorylation, but few have demonstrated a coordinate increase or decrease in enzymatic activity as a result. Described here is a novel S6 kinase isolated from human placenta which autoactivates through autophosphorylation in vitro. This S6/H4 kinase, purified in an inactive state, was shown to be a protein of Mr of 60,000 as estimated by SDS-PAGE and could catalyze the phosphorylation of the synthetic peptide S6-21, the histone H4, a…
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Date:
May 1994
Creator:
Dennis, Patrick B. (Patrick Brian)
Partner:
UNT Libraries