6 Matching Results

Search Results

Results: 1 - 6
open access

Relationship of Estrous Cycle to Herpes Simplex Virus Type 2 Susceptibility in Female Mice

Description: In CBA/NJ mice, splenic natural killer (NK) cell activity varies with stages of estrous. Susceptibility of ICR mice to intravaginal inoculation of herpes simplex virus type 2 (HSV-2) decreases with age. Susceptibility of female ICR and CBA/NJ mice to HSV-2 inoculated intravaginally and intraperitoneally was examined during the estrous cycle. In cycling ICR mice, greatest susceptibility to intravaginal inoculation was observed during diestrous and the least during metestrous. CBA/NJ mice were mo… more
Date: August 1987
Creator: Teepe, Annette
Partner: UNT Libraries
open access

Gold Compounds and Rheumatoid Arthritis Murine Studies of the Immune Response to Gold Sodium Thiomalate

Description: Balb/c normal mice were used to study the effects of gold sodium thiomalate (GST) on intact, nonadherent, and adherent mononuclear spleen cells. The three populations were tested for the following aspects: in vitro effects of GST on the mitogen-triggered DNA synthesis; intracellular levels of cyclic AMP; and chemotaxis ability. These studies showed that GST inhibited the proliferative responses of all three populations as the concentration of GST increased. Cyclic AMP levels in the nonadherent … more
Date: August 1986
Creator: Sayahtaheri, Sousan
Partner: UNT Libraries
open access

An Investigation of the Ratio of Free to Bound Phenytoin in Overdose Cases

Description: An investigation of the ratio of free to bound phenytoin in overdose cases was accomplished by three studies to answer these questions: 1. Will the free to bound ratio change with increasing total phenytoin concentration? 2. Will the free to bound ratio be altered with decreasing total protein concentration? 3. Do these results correlate with overdose cases? The results demonstrated that the ratio of free to bound phenytoin remains constant throughout the therapeutic range as long as a person h… more
Date: August 1985
Creator: Beckman Royder, Mona Lee
Partner: UNT Libraries
open access

Effects of Cigarette Smoke Condensates on Cultured Human Lymphocytes and Separation of Benzo-α-Pyrene Metabolites by High Pressure Liquid Chromatography

Description: Cigarette smoke condensates from all cigarettes tested were found to be potent inducers of AHH enzyme in cultured human lymphocytes and, with the exception of Kent Lights and Carlton CSC's, all were found to be toxic under the experiment conditions. Most of the AHH inducing activity was found in basic and neutral fractions of the lAl standard cigarettes. A radiometric assay of BP metabolites in cultured human lymphocytes was developed in which we were able to separate the primary metabolites an… more
Date: August 1979
Creator: Ghanayem, Burhan I.
Partner: UNT Libraries
open access

Characterization of the Molecular and Ionic Properties of the Histidine-Rich Protein Isolated From Newborn Rat Epidermis

Description: Histidine-rich protein from newborn rat epidermis has been further characterized. Polyacrylamide gel electrophoresis in 8 M urea demonstrated dissociation of the protein, a possible oligomeric series, and one major band with two minor bands of the, pH 5.0 precipitate. Amino acid analysis correlated well with previous analyses (except for lower levels of histidine), while the amino acids of high content increased with purification. Sedimentation coefficients and molecular weights determined by u… more
Date: August 1977
Creator: Tollefsbol, Trygve O.
Partner: UNT Libraries
open access

The Fate of Benzo(a)pyrene in Tissues of Mice Exposed to Diesel Exhaust

Description: Mice were exposed to diesel exhaust for 9 months prior to evaluation for benzo(a)pyrene disposition. On the last day of exposure the mice were instilled intratracheally with tritiated-benzo(a)pyrene ([3H]BP). The mice were sacrificed at intervals of 2, 24, and 168 hours. Disappearance of radioactivity from lungs and liver was rapid and essentially linear with time. In lungs, liver, and testes; [3H]BP metabolites were found mainly as conjugates, a form readily excretable. Clearance of the hydroc… more
Date: August 1981
Creator: Loudin, Agnes D.
Partner: UNT Libraries
Back to Top of Screen