Studies on ADP-Ribose Polymer Metabolism in Cultured Mammalian Cells Following DNA Damage
Description:
ADP-ribose polymer metabolism has been studied in human cells derived from a patient with Glutamyl Ribose Phosphate Storage Disease (GRPSD) and in mouse C3H1OT1/2 cells following oxidative stress induced by hydrogen peroxide (H202 ). It has been postulated that GRPSD resulted from an abnormality in ADP-ribose polymer metabolism. This study has shown that these cells exhibit reduced poly(ADP ribose) polymerase activity which is proposed to result from modification of the enzyme with ribose phosp…
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Date:
May 1991
Creator:
Maharaj, Geeta
Partner:
UNT Libraries