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Development of Biomimetic Human Lung Alveolus Chip

Description: The potential of physiologically relevant in vitro cell culture models for studying physiological and pathophysiological phenomena has been widely recognized as replacements for animal and conventional in vitro models. To create models that accurately replicate the structure and function of tissues and organs, it is essential to comprehend the biophysical and mechanical features of the extracellular matrix (ECM) and incorporate them into the in vitro cell culture models. Therefore, we first aim… more
Date: May 2023
Creator: Man, Kun
Partner: UNT Libraries

Differentiating Cardiac Organoids with Chamber Formations

Description: Considering that both cardiovascular disease (CVD) and congenital heart diseases (CHD) are still the leading cause of morbidity and mortality worldwide, there is a need for a robust and reliable cardiac model. Cardiac organoids are complex, three-dimensional cellular constructs that recapitulate the processes of the human embryonic heart. However, certain vital morphological features within the fetus are not yet replicable with cardiac organoids. Here we report our investigation to generate car… more
This item is restricted from view until August 1, 2024.
Date: July 2023
Creator: Seddoh, Percyval Prince-Danny
Partner: UNT Libraries
open access

Modeling of Hypertrophic Cardiomyopathy Using hiPSC-Derived Cardiomyocytes with Static Mechanical Stretching

Description: The heart is a dynamic environment that is constantly experiencing some degree of remodeling from the point of development, all the way through adulthood. While many genetic components may contribute to the overall presentation of hypertrophic cardiomyopathy (HCM), mutations occurring in sarcomere components such as myosin binding protein C3 (MYBPC3) are of the greatest popularity for study. Aiming to understand the mechanisms underlying heart diseases and to develop effective treatments that c… more
Date: May 2023
Creator: Rogozinski, Nicholas
Partner: UNT Libraries

Novel Phase-Chance Soft Actuators Controlled via Peltier

Description: Soft actuation methods are a developing field of robotics deemed suitable for physical human-robot interactions due to the adaptability of materials and compliant structures. Thermo-active soft actuators are a subset of these which convert thermal energy to mechanical work in the form of elongation, bending, or twisting to conform to the environment. This study is divided into three major studies that all use actuators with a working principle of phase-change fluid vaporizing for expansion with… more
Date: July 2023
Creator: Johnson, Daniel Cody
Partner: UNT Libraries

Engineering a Microfluidic Blood-Brain Barrier on a Silicon Chip

Description: The blood-brain barrier (BBB) is composed of brain microvascular endothelial cells (BMECs), pericytes, and astrocytic endfeet, which regulate the transport of molecules into and out of the brain. BMECs possess intrinsic barrier properties that limit the passage of approximately 98% of small molecules into the brain in healthy individuals. However, in some brain diseases, the BBB undergoes structural and functional alterations, which can contribute to disease progression. In this study, we aimed… more
Date: July 2023
Creator: Liu, Jiafeng
Partner: UNT Libraries

Development and Characterization of Compliant Bioelectronic Devices for Gastrointestinal Stimulation

Description: In this research, we aimed to develop thin-film devices on a polymer substrate and an alternative 3D-printed device with macroelectrodes for treating gastrointestinal (GI) conditions. First, the fabrication of thin-film devices was demonstrated on a softening thiol-ene/acrylate polymer utilizing titanium nitride (TiN) as electrode material. This was achieved by utilizing cleanroom fabrication processes such as photolithography, wet and dry etching. The functionality of the device was shown by p… more
This item is restricted from view until January 1, 2026.
Date: December 2023
Creator: Chitrakar, Chandani
Partner: UNT Libraries

Mesenchymal Stem Cells Encapsulated and Aligned in Self-Assembling Peptide Hydrogels

Description: This study presents a viable strategy using fmoc-protected peptides hydrogels, to encapsulate and stretch mesenchymal stem cells (MSC). To explore the peptide hydrogel potential, a custom mechanical stretching device with polydimethylsiloxane (PDMS) chambers were used to stretch MSCs encapsulated in Fmoc hydrogels. We investigated the impact of fmoc- FF prepared in dimethyl sulfoxide (DMSO), 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) and deionizied water in the self-assembly, and mechanical proper… more
This item is restricted from view until January 1, 2025.
Date: December 2023
Creator: Kasani, Yashesh Varun
Partner: UNT Libraries

Magnetoresponsive Layer-by-Layer (LBL) Polyelectrolyte Microcapsules Exposed to Low Frequency Alternating Magnetic Field for Drug Delivery to Breast Cancer Cells

Description: Layer-by-layer (LBL) polyelectrolyte capsules can be modified to incorporate stimuli such as superparamagnetic nanoparticles which respond to a magnetic field only when it is turned on. Thus, they can act as a switch to load or unload their drug cargo on demand. Specifically, magnetite is incorporated into bilayer capsules made of alternating poly(allylamine hydrochloride) (PAH) and poly(sodium-p-styrenesulfonate) (PSS) which surrounds calcium carbonate core. The core is then dissolved using… more
This item is restricted from view until January 1, 2025.
Date: December 2023
Creator: Powell, Robert Darrel
Partner: UNT Libraries
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