Role of 5.8S rRNA in Zebrafish and Human Blood Coagulation
Description:
Hemolytic disorders are characterized by hemolysis and are prone to thrombosis. Previously, it has been shown that the RNA released from damaged blood cells activates clotting. However, the nature of RNA released from hemolysis is still elusive. We found that after hemolysis, the red blood cells from both zebrafish and humans release 5.8S rRNA. This RNA activated coagulation in zebrafish and human plasmas. Using both natural and synthetic 5.8S rRNA and its synthetic truncated fragments, we foun…
more
Date:
December 2020
Creator:
Alharbi, Abdulmajeed Haya M.
Partner:
UNT Libraries