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open access

An Investigation of the Ratio of Free to Bound Phenytoin in Overdose Cases

Description: An investigation of the ratio of free to bound phenytoin in overdose cases was accomplished by three studies to answer these questions: 1. Will the free to bound ratio change with increasing total phenytoin concentration? 2. Will the free to bound ratio be altered with decreasing total protein concentration? 3. Do these results correlate with overdose cases? The results demonstrated that the ratio of free to bound phenytoin remains constant throughout the therapeutic range as long as a person h… more
Date: August 1985
Creator: Beckman Royder, Mona Lee
Partner: UNT Libraries
open access

Discriminative Stimulus Properties of Cocaine: Tolerance and Cross-Tolerance Characteristics

Description: Rats were trained to discriminate an injection of cocaine, 5.0 mg/kg, from an injection of saline, using a two-lever choice paradigm: one lever was correct after cocaine injection, the other lever was correct after a saline injection. After training, cocaine and methamphetamine were generalized to the cocaine lever, but phenethylamine (PEA) was only partially generalized. Cocaine was injected every 8 hrs, 20.0 mg/kg, and the discriminability of 5.0 mg/kg was tested every other day. Redetermina… more
Date: May 1985
Creator: Wood, Douglas M. (Douglas Michael)
Partner: UNT Libraries
open access

The Relationship of Dose to Plasma Concentration with Acute Ingestion of Amitriptyline

Description: The high concentrations of amitriptyline found in blood at autopsy, indicating a large amount of ingested drug, is often contradictory to the prescription available. Using dogs as the animal model it was found that there was a large variance between the dose given and its plasma amitriptyline concentration during the acute phase of absorption. Factors that were found to be important were the amitriptyline to nortriptyline (as metabolite) ratio, the nature of the specimen, and the collection sit… more
Date: May 1985
Creator: Williams, Teresa Lynn
Partner: UNT Libraries
open access

Exoprotease Production by Aeromonas hydrophila in a Chemically Defined Medium

Description: Wretlind, Heden, and Wadstrom found ammonium sulfate to be inhibitory for the formation of extracellular protease in Aeromonas hydrophila grown in Brain Heart Infusion medium. They demonstrated by manipulating the iron and zinc content within their medium that it is possible to differentially affect the accumulation of hemolysin and protease by A. hydrophila grown in batch culture. Further manipulation of the composition of this medium was done in the present study to determine the effect of ot… more
Date: May 1985
Creator: Anderson, Paulette S. (Paulette Sue), 1952-
Partner: UNT Libraries
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