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open access

Microfabrication of an Implantable silicone Microelectrode array for an epiretinal prosthesis

Description: Millions of people suffering from diseases such as retinitis pigmentosa and macular degeneration are legally blind due to the loss of photoreceptor function. Fortunately a large percentage of the neural cells connected to the photoreceptors remain viable, and electrical stimulation of these cells has been shown to result in visual perception. These findings have generated worldwide efforts to develop a retinal prosthesis device, with the hope of restoring vision. Advances in microfabrication, i… more
Date: June 10, 2003
Creator: Maghribi, M
Partner: UNT Libraries Government Documents Department
open access

Geometry, topology, and string theory

Description: A variety of scenarios are considered which shed light upon the uses and limitations of classical geometric and topological notions in string theory. The primary focus is on situations in which D-brane or string probes of a given classical space-time see the geometry quite differently than one might naively expect. In particular, situations in which extra dimensions, non-commutative geometries as well as other non-local structures emerge are explored in detail. Further, a preliminary exploratio… more
Date: July 10, 2003
Creator: Varadarajan, Uday
Partner: UNT Libraries Government Documents Department
open access

Structural studies of conformational changes of proteins upon phosphorylation: Structures of activated CheY, CheY-N16-FliM complex, and AAA {sup +} ATPase domain of NtrC1 in both inactive and active states

Description: Protein phosphorylation is a general mechanism for signal transduction as well as regulation of cellular function. Unlike phosphorylation in eukaryotic systems that uses Ser/Thr for the sites of modification, two-component signal transduction systems, which are prevalent in bacteria, archea, and lower eukaryotes, use an aspartate as the site of phosphorylation. Two-component systems comprise a histidine kinase and a receiver domain. The conformational change of the receiver domain upon phosphor… more
Date: April 10, 2003
Creator: Lee, Seok-Yong
Partner: UNT Libraries Government Documents Department
open access

Maskless, resistless ion beam lithography

Description: As the dimensions of semiconductor devices are scaled down, in order to achieve higher levels of integration, optical lithography will no longer be sufficient for the needs of the semiconductor industry. Alternative next-generation lithography (NGL) approaches, such as extreme ultra-violet (EUV), X-ray, electron-beam, and ion projection lithography face some challenging issues with complicated mask technology and low throughput. Among the four major alternative NGL approaches, ion beam lithogra… more
Date: March 10, 2003
Creator: Ji, Qing
Partner: UNT Libraries Government Documents Department
open access

Characterizing the Material Properties of Polymer-Based Microelectrode Arrays for Retinal Prosthesis

Description: The Retinal Prosthesis project is a three year project conducted in part at the Lawrence Livermore National Laboratory and funded by the Department of Energy to create an epiretinal microelectrode array for stimulating retinal cells. The implant must be flexible to conform to the retina, robust to sustain handling during fabrication and implantation, and biocompatible to withstand physiological conditions within the eye. Using poly(dimethyl siloxane) (PDMS), LLNL aims to use microfabrication te… more
Date: May 10, 2003
Creator: Park, C S & Maghribi, M
Partner: UNT Libraries Government Documents Department
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