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open access

Quantitative Studies of Inhibitors of ADP-ribosylation in Vitro and in Vivo

Description: Article evaluating the selectivity of compounds originally identified as inhibitors of poly(ADP-ribose) polymerase on members of the three classes of enzymes. The results suggest that micromolar levels of the benzamides in the culture medium should allow selective inhibition of poly(ADP-ribose) metabolism in intact cells. Furthermore, comparative quantitative inhibition studies should prove useful for assigning the biological effects of these inhibitors as an effect on either poly(ADP-ribose) o… more
Date: March 15, 1989
Creator: Rankin, Patrick W.; Jacobson, Elaine L.; Benjamin, Robert C.; Moss, Joel & Jacobson, Myron K.
Partner: University of North Texas
open access

Traffic generated emissions alter the lung microbiota by promoting the expansion of Proteobacteria in C57Bl/6 mice placed on a high-fat diet

Description: Article investigating exposure to traffic-generated emissions and the potential to alter lung microbiota and immune defenses. Results show that the combined effects of ME and HF diet result in decreased immune surveillance and lung bacterial dysbiosis, which is of significance in lung diseases.
Date: April 15, 2021
Creator: Daniel, Sarah; Pusadkar, Vaidehi; McDonald, Jacob D.; Mirpuri, Julie; Azad, Rajeev K.; Goven, Art et al.
Partner: University of North Texas
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