A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy
Description:
This article gives an overview of the discovery of small-molecule bioprecursor prodrugs carrying the para-quinol scaffold on the steroidal A-ring that are preferentially metabolized in the CNS to the corresponding estrogens. Selected examples are shown to illustrate that, independently of the route of administrations and duration of treatments, these agents produce high concentration of estrogens only in the CNS without peripheral hormonal liability. 10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)…
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Date:
November 19, 2019
Creator:
Prokai-Tatrai, Katalin & Prókai, László, 1958-
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Partner:
UNT Health Science Center