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NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner

Description: This article's study endeavors to determine if p53 is responsible for cisplatin sensitization by NSC109268. Results have implications for sensitivity of ovarian cancer cells to cisplatin independent of p53.
Date: October 5, 2010
Creator: Shankar, Eswar; Basu, Chandreyi; Adkins, Brett; Siede, Wolfram & Basu, Alakananda
Item Type: Refine your search to only Article
Partner: UNT Health Science Center
open access

Regulation of Autophagy by Kinases

Description: This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.
Date: June 9, 2011
Creator: Sridharan, Savitha; Jain, Kirti & Basu, Alakananda
Item Type: Refine your search to only Article
Partner: UNT Health Science Center
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