Quantitative Studies of Inhibitors of ADP-ribosylation in Vitro and in Vivo
Description:
Article evaluating the selectivity of compounds originally identified as inhibitors of poly(ADP-ribose) polymerase on members of the three classes of enzymes. The results suggest that micromolar levels of the benzamides in the culture medium should allow selective inhibition of poly(ADP-ribose) metabolism in intact cells. Furthermore, comparative quantitative inhibition studies should prove useful for assigning the biological effects of these inhibitors as an effect on either poly(ADP-ribose) o…
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Date:
March 15, 1989
Creator:
Rankin, Patrick W.; Jacobson, Elaine L.; Benjamin, Robert C.; Moss, Joel & Jacobson, Myron K.
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Partner:
University of North Texas