Existence of an Alpha One-Adrenoceptor-Mediated Coronary Vasoconstrictor Reflex During Acute Systemic Hypoxia, in Anesthetized, Open-Chest Dogs
Description:
The presence of an alpha-adrenoceptor--mediated coronary vasoconstrictor reflex during acute systemic hypoxia was examined in thirteen chloralose-anesthetized dogs. Local vasodilator effects were avoided by perfusing the left common coronary artery (LCC) with normoxic blood, while the dogs were ventilated with 5% 02-95% N2 . Left ventricular afterload was held constant and positive cardiac inotropic responses and beta two-adrenoceptor-mediated coronary vasodilation were blocked by propranolol. …
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Date:
December 1987
Creator:
Grice, Derald Preston
Partner:
UNT Libraries