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Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro

Description: The article looks at antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for pol… more
Date: April 15, 2011
Creator: Carraher, Charles E., Jr.; Roner, Michael R.; Shahi, Kimberly & Barot, Girish
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
open access

In situ cardiac performance of Atlantic cod (Gadus morhua) at cold temperatures: long-term acclimation, acute thermal challenge and the role of adrenaline

Description: This article measures the cardiac performance of Newfoundland Atlantic cod (Gadus morhua). The results: (1) show that maximum performance of the isolated cod heart is not compromised by exposure to cold temperatures; and (2) support data from other studies, which show that, in contrast to salmonids, cod cardiac performance/myocardial contractility is not dependent upon humoral adrenergic stimulation.
Date: November 15, 2012
Creator: Lurman, Glenn J. & Petersen, L. H.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

Constraints-based stoichiometric analysis of hypoxic stress on steroidogenesis in fathead minnows, Pimephales promelas

Description: This article presents a study in which an in silico genome-scale metabolic model of steroidogenesis is used to investigate the effects of hypoxic stress on steroid hormone productions in fish. This article introduces a powerful model for pathway analysis that can lend insights on the effects of various stressor scenarios on metabolic functions.
Date: May 15, 2012
Creator: Hala, David; Petersen, Lene H.; Martinovic, Dalma & Huggett, Duane B.
Item Type: Refine your search to only Article
Partner: UNT Institute of Applied Sciences
open access

Xenopus and the art of oxygen maintenance

Description: This column article discusses the impact of Robert Boutillier and Graham Shelton's 1986 Journal of Experimental Biology paper "Gas exchange, storage and transport in voluntarily diving Xenopus laevis."
Date: November 15, 2017
Creator: Tattersall, Glenn & Burggren, Warren W.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

Leukocyte Subset Changes in Response to a 164-km Road Cycle Ride in a Hot Environment

Description: This article determines the circulating leukocyte subset response to completing the 2013 Hotter'N Hell Hundred recreational 164-km road cycle event in a hot and humid environmental condition.
Date: January 15, 2016
Creator: Luk, Hui-Ying; McKenzie, Amy L.; Duplanty, Anthony A.; Budnar, Ronald; Levitt, Danielle; Fernandez, Alex et al.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
open access

Activation of an S6 Kinase From Human Placenta by Autophosphorylation

Description: Article describing a novel S6 kinase isolated from human placenta which autoactivates through autophosphorylation in vitro. The data supports the hypothesis that this previously uncharacterized S6 kinase belongs to a unique family of protein kinases which utilize autophosphorylation as part of their in vivo activation mechanism.
Date: September 15, 1993
Creator: Dennis, Patrick B. & Masaracchia, Ruthann A.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

Quantitative Studies of Inhibitors of ADP-ribosylation in Vitro and in Vivo

Description: Article evaluating the selectivity of compounds originally identified as inhibitors of poly(ADP-ribose) polymerase on members of the three classes of enzymes. The results suggest that micromolar levels of the benzamides in the culture medium should allow selective inhibition of poly(ADP-ribose) metabolism in intact cells. Furthermore, comparative quantitative inhibition studies should prove useful for assigning the biological effects of these inhibitors as an effect on either poly(ADP-ribose) o… more
Date: March 15, 1989
Creator: Rankin, Patrick W.; Jacobson, Elaine L.; Benjamin, Robert C.; Moss, Joel & Jacobson, Myron K.
Item Type: Refine your search to only Article
Partner: University of North Texas
open access

Accumulation of Flavonols over Hydroxycinnamic Acids Favors Oxidative Damage Protetion under Abiotic Stress

Description: This article reports on the characterization of the different antioxidant mechanisms of tomato plants subjected to heat stress, salinity stress, or a combination of both stresses.
Date: June 15, 2016
Creator: Martinez, Vicente; Mestre, Teresa C.; Rubio, Francisco; Girones-Vilaplana, Amadeo; Moreno, Diego; Mittler, Ron et al.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
open access

Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil

Description: This article establishes the de novo transcriptomic database from the embryos and larvae of mahi-mahi exposed to water accommodated fractions (HEWAFs) of two Deepwater Horizon oil types (weathered and source oil) in an effort to advance understanding of the molecular aspects involved during specific toxicity responses.
Date: March 15, 2017
Creator: Xu, Elvis Genbo; Mager, Edward M.; Grosell, Martin; Hazard, E. Starr; Hardiman, Gary & Schlenk, Daniel
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
open access

Low neutral genetic diversity in isolated Greater Sage-Grouse (Centrocercus urophasianus) populations in northwest Wyoming

Description: This article contains an analysis of 16 microstatellite loci from 300 Greater Sage-Grouse individuals to assess genetic structure among populations in Wyoming and southeast Montana.
Date: October 15, 2014
Creator: Schulwitz, Sarah; Bedrosian, Bryan & Johnson, Jeff A.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
open access

NSFDEB-NERC: Collaborative Research: Wildlife corridors: do they work and who benefits?

Description: Data management plan for the grant, "NSFDEB-NERC: Collaborative Research: Wildlife corridors: do they work and who benefits?" Research on the impact of wildlife corridors using genetics as the measure of effectiveness. The study will use 20 independent landscapes to quantify how corridor traits affect gene flow, and will use non-flying mammals as focal species because they are strongly affected by fragmentation. The research team hypothesizes (1) a strong non-linear decline in success (gene flo… more
Date: 2021-01-15/2023-12-31
Creator: Gregory, Andrew
Item Type: Refine your search to only Text
Partner: UNT College of Science
open access

Vehicle emissions-exposure alters expression of systemic and tissue-specific components of the renin-angiotensin system and promotes outcomes associated with cardiovascular disease and obesity in wild-type C57BL/6 male mice

Description: This article investigates the hypothesis that exposure to engine emissions increases systemic and local adipocyte RAS signaling, promoting the expression of factors involved in cardiovascular disease and obesity.
Date: April 15, 2021
Creator: Phipps, Benjamin L.; Suwannasual, Usa; Lucero, JoAnn; Mitchell, Nicholas A. & Lund, Amie K.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

The protein conformational basis of isoflavone biosynthesis

Description: Authors of the article assert that isoflavonoids play important roles in plant defense and also exhibit a range of mammalian health-promoting activities. They emphasize that understanding the structural basis of isoflavone biosynthesis will facilitate the engineering of new bioactive isoflavonoids.
Date: November 15, 2022
Creator: Wang, Xiaoqiang; Pan, Haiyun; Sagurthi, Someswar; Paris, Vincent; Zhuo, Chunliu & Dixon, R. A.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers

Description: This article contains a study to determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.
Date: August 15, 2017
Creator: McFarlin, Brian K.; Henning, Andrea L.; Bowman, Erin M.; Gary, Melody A. & Carbajal, Kimberly M.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

A cytochrome P450 monooxygenase commonly used for negative selection in transgenic plants causes growth anomalies by disrupting brassinosteroid signaling

Description: Article on a cytochrome P450 monooxygenase commonly used for negative selection in transgenic plants causing growth anomalies by disrupting brassinosteroid signaling.
Date: April 15, 2011
Creator: Dasgupta, Kasturi; Ganesan, Savita; Manivasagam, Sindhu & Ayre, Brian G.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences

Adopt-A-Molecule: A guided Inquiry for Increasing Student Interest in Organic Chemistry [Presentation]

Description: Presentation for the 2010 University Scholars Day at the University of North Texas. This presentation discusses research on the Adopt-A-Molecule project, a 9-week long, two-part term project, undertaken by students enrolled in the first of the two-semester sequence in organic chemistry (Fall 2009).
Date: April 15, 2010
Creator: Musgrave, Paul & Dandekar, Sushama Ashok
Item Type: Refine your search to only Presentation
Partner: UNT Honors College

Isolation and Characterization of Novel Microbacteriophage Barbara

Description: Poster presentation for the 2010 University Scholars Day at the University of North Texas discussing research on the isolation of a new strain of mycobacteriophage from soil collection using a Mycobacterium smegmatis host strain and an enrichment protocol.
Date: April 15, 2010
Creator: Mitchell, Angel; Simon, Stephanie E.; Benjamin, Robert C. & Hughes, Lee E.
Item Type: Refine your search to only Poster
Partner: UNT Honors College
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