11 Matching Results

Explore Results

Results: 1 - 11
open access

Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding

Description: Data management plan for the grant "Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding." This project seeks to demonstrate proof-of-concept for technology that allows one to systematically place cells on substrates to create complex 3D assemblies with precise control over individual cellular interactions. The technology generated within this proposal will open new avenues for studying multicellular communication pathways, stem cell differentiation, and understandi… more
Date: 2021-09-01/2023-08-31
Creator: Meckes, Brian
Partner: UNT College of Engineering
open access

Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors

Description: Data management plan for the grant "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors." This research is expected to advance the capability to engineer organisms for biomedical uses. Specifically, the outcomes of this project include design principles for engineering regulators from different protein families, an extensive set of genetic sensors for detecting a broad range of signals, and novel genetic circuits that address uprising problems in biomedical fields.… more
Date: 2021-09-15/2026-08-31
Creator: Chan, Clement T. Y.
Partner: UNT College of Engineering
open access

CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients

Description: Data management plan for the grant "CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients." This NSF Faculty Early Career Development (CAREER) project will develop novel networks of flexible Peltier-based soft actuators designed for rehabilitation.
Date: 2021-10-01/2026-03-31
Creator: Jafari, Amir
Partner: UNT College of Engineering
open access

New approach for identification pHFO networks to predict epilleptogenesis

Description: Data management plan for the grant, "New approach for identification pHFO networks to predict epilleptogenesis." About 40% of epilepsy patients fail to control seizures after treatment, and currently there is no treatment that can prevent epilepsy. The goal of this study is to perform multi-scale electrophysiological investigations combine with advanced computational algorithm development to understand the characteristics of the pathological brain networks during the latent period of epilepsy. … more
Date: 2022-07-15/2026-06-30
Creator: Li, Lin
Partner: UNT College of Engineering
open access

CAREER: Shape Memory Polymers as Biomaterial

Description: Data management plan for the grant, "CAREER: Shape Memory Polymers as Biomaterial." This CAREER projectaimsto elucidate the underlying mechanism of the plasticization-induced shape memory effect of thiol-enebased polymers. The model application for this material will be a heat shrink tubing that can shrink at bodily conditions (37° C and simulated body fluids) and can be used to seal colonic anastomosis. The specific three aims are to (1) Systematically investigate the effect of crosslink-densi… more
Date: 2023-02-01/2028-01-31
Creator: Ecker, Melanie
Partner: UNT College of Engineering
open access

New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers

Description: Data management plan for the grant, "New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers." In this project, we propose the development of selective self-assembling peptides that form nanofibers via a self-assembling process upon the action of Eyes absent (EYA) enzyme, specific to drug resistance Triple Negative Breast cancer cells (TNBC). The objectives are: Aim 1: Design and synthesize self-assembling peptide substrates for EYA enzymes; Aim 2:Deter… more
Date: 2023-08-17/2024-07-31
Creator: Habibi, Neda
Partner: UNT College of Engineering
open access

Child Health and Human Development Extramural Research

Description: Data management plan for the grant, "Child Health and Human Development Extramural Research." This study will use the genome-edited human induced pluripotent stem cell (hiPSC) with NOTCH1 knockout to recapitulate the genetic variants of NOTCH1 mutation in the Hypoplastic left heart syndrome (HLHS). It will use advances in the vascularized cardiac organoid directly differentiated from hiPSCs to replay the development and function of cardiomyocytes, endothelial cells, smooth muscle cells, and oth… more
Date: 2022-09-08/2025-08-31
Creator: Yang, Huaxiao
Partner: UNT College of Engineering
open access

Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration

Description: Data management plan for the grant, "Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration." The most prominent causative risk factor of glaucoma, the leading cause of irreversible blindness worldwide, is elevated intraocular pressure (IOP), which could deform the optic nerve head (ONH) and cause glaucomatous neurodegeneration. However, current glaucoma therapies that focus on lowering IOP do not stop vision loss effectively, and thus there is a pressing need to understand the mechani… more
Date: 2022-09-30/2025-05-31
Creator: Yang, Yong
Partner: UNT College of Engineering
Back to Top of Screen